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EC number: 412-260-6 | CAS number: 52658-19-2 MONO 442
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data provided by ECHA on request of Cytec Surface Specialties NV/SA. SNIF last update on 1993-10-25, UUID: SNIF-9afcc480-fb63-3500-a144-c5b56bbd2ec7.
Data source
Reference
- Reference Type:
- other: "Information from migrated NONS file, as per inquiry number 06-0000014943-66-0000, permission to refer granted by ECHA
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- Annex V
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of: 7,9,9-trimethyl-3,14-dioxa-4,13-dioxo-5,12-diazahexadecane-1,16-diylprop-2-enoate; 7,7,9-trimethyl-3,14-dioxa-4,13-dioxo-5,12-diazahexadecan-1,16-diylprop-2-enoate
- EC Number:
- 412-260-6
- EC Name:
- A mixture of: 7,9,9-trimethyl-3,14-dioxa-4,13-dioxo-5,12-diazahexadecane-1,16-diylprop-2-enoate; 7,7,9-trimethyl-3,14-dioxa-4,13-dioxo-5,12-diazahexadecan-1,16-diylprop-2-enoate
- Cas Number:
- 52658-19-2
- Molecular formula:
- C21H34N2O8 (molecular formula of the two isomers constituting the substance)
- IUPAC Name:
- 2-({[(2R)-2,4,4-trimethyl-6-({[2-(prop-2-enoyloxy)ethoxy]carbonyl}amino)hexyl]carbamoyl}oxy)ethyl prop-2-enoate; 2-({[(2S)-2,4,4-trimethyl-6-({[2-(prop-2-enoyloxy)ethoxy]carbonyl}amino)hexyl]carbamoyl}oxy)ethyl prop-2-enoate; 2-({[(3R)-3,5,5-trimethyl-6-({[2-(prop-2-enoyloxy)ethoxy]carbonyl}amino)hexyl]carbamoyl}oxy)ethyl prop-2-enoate; 2-({[(3S)-3,5,5-trimethyl-6-({[2-(prop-2-enoyloxy)ethoxy]carbonyl}amino)hexyl]carbamoyl}oxy)ethyl prop-2-enoate; 2-({[2,2,4-trimethyl-6-({[2-(prop-2-enoyloxy)ethoxy]carbonyl}amino)hexyl]carbamoyl}oxy)ethyl prop-2-enoate; 2-({[2,4,4-trimethyl-6-({[2-(prop-2-enoyloxy)ethoxy]carbonyl}amino)hexyl]carbamoyl}oxy)ethyl prop-2-enoate
- Details on test material:
- - Substance type: Very viscous clear yellowish liquid
- Physical state: liquid
- Analytical purity: >=95%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hoe: WISKf (SPF 71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not stated
- Age at study initiation: not stated
- Weight at study initiation: not stated
- Fasting period before study: not stated
- Housing: not stated
- Diet (e.g. ad libitum): not stated
- Water (e.g. ad libitum): not stated
- Acclimation period: not stated
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not stated
- Humidity (%): not stated
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): not stated
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: sezam oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: not stated
- % coverage: not stated
- Type of wrap if used: not stated
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not stated
- Time after start of exposure: not stated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg b.w.
- Concentration (if solution): not stated
- Constant volume or concentration used: not stated
- For solids, paste formed: not stated
VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity: not stated
TEST SITE
- Area of exposure: not stated
- % coverage: not stated
- Type of wrap if used: not stated
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not stated
- Time after start of exposure: not stated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity: not stated - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg b.w. Number of animals: 5; number of deaths: 0
Female: 2000 mg/kg b.w. Number of animals: 5; number of deaths: 0 - Clinical signs:
- other: No signs of toxicity related to dose levels. No signs of systemic toxicity were observed.
- Gross pathology:
- Effects on organs:
No macroscopic abnormalities were observed. - Other findings:
- Signs of toxicity (local):
Slight of well defined erythema was observed in all animals from day 2 onwards. This was accompanied in most by scaling, encrustations, indurations of a dry, rough surface. By day 7 on the males and day 13 in the females all skin sites were normal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- Under the study conditions, the single dose acute dermal LD50 of the test substance is greater than 2000 mg/kg bw/d in male and female rats.
- Executive summary:
A study was conducted to determine the acute dermal toxicity of the test substance to rat according to EU Method B.3. A single dose of the test substance at 2000 mg kg/bw was applied to the skin of ten healthy rats for 24 h. The animals were observed for mortality, body weights, signs of gross toxicity, and behavioral changes for 14 d. Slight to well-defined erythema was observed in all animals from Day 2 onwards. This was accompanied in most by scaling, encrustations, indurations of a dry, rough surface. By Day 7 in the males and Day 13 in the females, all skin sites were normal. Under the study conditions, the acute dermal LD50 of the test substance was greater than 2000 mg/kg bw in rats (Anonymous, 1993).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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