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EC number: 225-207-5 | CAS number: 4717-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-08-27 to 2018-09-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- None
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- -Concentrations: Samples of all concerntration were taken at the initiation and after 5 days
- Buffers:
Preparation of Buffer solution
pH 4.0: The solution was prepared by mixing 4.5mL of 1 mol/L sodium hydroxide solution and 50mL of 0.5 mol/L potassium dihydrogen citrate solution and then filling up to 500mL with purified water, and then adjusting the pH 4.0 with 1 mol/L hydrochloric acid.
pH 7.0: The solution was prepared by mixing 14.8mL of 1 mol/L sodium hydroxide solution and 50mL of 0.5 mol/L potassium dihydrogen phosphate solution and then filling up to 500mL with purified water, and then adjusting the pH 7.0 with 1 mol/L hydrochloric acid
pH 9.0: The solution was prepared by mixing 10.7ml of 1 mol/L sodium hydroxide solution and 50mL of 0.5 mol/L potassium chloride solution and 0.5 mol/L boric acid solution, and then filling up to 500mL with purified water, and then adjusting the pH 9.0 with 1 mol/L hydrochloric acid
The buffer solution was filtered with a sterile filter after the preparation.- Preliminary study:
- The test item is hydrolytically stable at pH 4.0, pH 7.0 and pH 9.0.
- Transformation products:
- no
- % Recovery:
- ca. 101
- pH:
- 9
- Duration:
- ca. 5 d
- % Recovery:
- ca. 96.1
- pH:
- 7
- Duration:
- ca. 5 d
- % Recovery:
- ca. 98.3
- pH:
- 4
- Duration:
- ca. 5 d
- pH:
- 9
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 4
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
The test item is hydrolytically stable at pH 4.0, pH 7.0 and pH 9.0.- Results with reference substance:
- No adverse effect on the reliability of this test were noted. The test item is hydrolytically stable at pH 4.0, pH 7.0 and pH 9.0.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The residual percentage of test item at each pH was larger than 90%. Therefore, the test item is hydrolytically stable at pH 4.0, pH 7.0 and pH 9.0.
Reference
Table 1: The pH of test solutions at initiations are shown as follows
Test solution | pH of test solution ( at initiation) |
pH4.0 | 4.0 |
pH7.0 | 7.0 |
pH9.0 | 9.0 |
Table 2: The Residual Percentage of the test item
Test solution | Concentration (mg/L) | Residual percentage | ||
At Initiation | After 5days |
| Average | |
pH4.0 | 421 | 412 | 97.8 | 98.3
|
417 | 98.9 | |||
pH7.0 | 430 | 415 | 96.6 | 96.1 |
411 | 95.6 | |||
pH9.0 | 407 | 413 | 101 | 101 |
413 | 101 |
Description of key information
The residual percentage of test item at each pH was larger than 90%. Therefore, the test item is hydrolytically stable at pH 4.0, pH 7.0 and pH 9.0.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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