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EC number: 205-182-7 | CAS number: 135-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- one of several accessible publications that are available in scientific literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures: A comparison with bacterial mutagenicity using 218 compounds
- Author:
- Gregory S. Probst
Robert E. McMahon
L. E. Hill
Christina Z. Thompson
J. K. Epp
S. B. Neal - Year:
- 1 981
- Bibliographic source:
- Probst, G. S., McMahon, R. E., Hill, L. E., Thompson, C. Z., Epp, J. K. and Neal, S. B. (1981), Environ. mutagen, 3: 11-32.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-naphthol
- EC Number:
- 205-182-7
- EC Name:
- 2-naphthol
- Cas Number:
- 135-19-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- 2-naphthol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Aldrich Chemical Co, Milwaukee, Wisconsin
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium, other: G46
- Species / strain / cell type:
- S. typhimurium TA 1535
- Species / strain / cell type:
- S. typhimurium, other: TA1000
- Species / strain / cell type:
- S. typhimurium, other: C3076
- Species / strain / cell type:
- S. typhimurium TA 1537
- Species / strain / cell type:
- S. typhimurium, other: D3052
- Species / strain / cell type:
- S. typhimurium TA 1538
- Species / strain / cell type:
- S. typhimurium TA 98
- Species / strain / cell type:
- E. coli WP2
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Details on test system and experimental conditions:
- Bacterial mutagenesis was measured by a modification of the Ames test utilizing concentration gradient plates as described by McMahon et al. Briefly, inocula of ten bacterial tester strains were streaked across square agar plates containing a concentration gradient of test compound and mutagenicity was scored by noting the number of tester strains showing mutant colonies over a given concentration range. The test was conducted using eight histidine auxotrophs of Salmonella typhimurium (G46, TA1535, TAlOOO, C3076, TA1537, D3052, TA1538, and TA98) and two tryptophan auxotraphs of Escherichia coli (WP2 and WP2 uvrA-). Each compound was incorporated into four gradient plates to give a tenfold concentration range per plate, thus providing a 10,000-fold concentration range for the test. For metabolic activation, an S9 fraction, derived from the livers of Aroclor 1254 pretreated rats, was mixed with appropriate co-factors and included in an agar overlay on the gradient plates. Each compound was tested with and without metabolic activation. The data reported here include the number and identity of tester strains showing revertant colonies as well as an estimate of the minimal chemical concentration which produced revertants in the most sensitive tester strain.
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium, other: G46
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium, other: TA1000
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium, other: C3076
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium, other: D3052
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium, other: TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- E. coli WP2
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Key result
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- 2-Naphthol was not mutagenic in a bacterial reverse mutation test (see Probst, G. S., McMahon, R. E., Hill, L. E., Thompson, C. Z., Epp, J. K. and Neal, S. B. (1981), Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures: A comparison with bacterial mutagenicity using 218 compounds. Environ. mutagen, 3: 11-32.)
- Executive summary:
2-Naphthol was not mutagenic in several Ames-tests using Salmonella typhimurium strains TA 98, TA100, TA 1535, TA 1537, TA 1538, G46, C3076, D3052, and Escherichia coli WP2uvrA, both in the presence and in the absence of metabolic activation (liver S-9 mix) and including cytotoxic concentrations (Probst et al., 1981; Purchase et al., 1978; Muzall and Cook, 1979; Florin et al., 1980).
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