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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05 Oct 2017 - 10 Nov 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
(2R)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
Cas Number:
93601-85-5
Molecular formula:
C14H21NO.HCl
IUPAC Name:
(2R)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
Constituent 2
Chemical structure
Reference substance name:
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)
EC Number:
695-797-0
Cas Number:
93601-86-6
Molecular formula:
C14H21NO.HCl
IUPAC Name:
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)
Test material form:
solid: particulate/powder
Details on test material:
- Appearance: White to off-white powder
- Storage condition of test material: At room temperature

Results and discussion

Water solubility
Key result
Water solubility:
10.8 g/L
Conc. based on:
test mat.
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 6.5 - <= 6.6
Details on results:

-Concentration analysed after 24, 48 and 72 hours of stirring: 10.9 g/L, 10.7 g/L and 10.9 g/L, resp.
-Maximum difference meets the criterion of ≤ 15% (i.e. 2.5%)
-The mean of the three concentrations was reported as the water solubility of the substance.

Applicant's summary and conclusion

Conclusions:
The water solubility of the substance at 20°C was determined to be 10.8 g/L.
Executive summary:

The water solubility of the substance was determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UPLC-UV. The pH of the aqueous samples was 6.5-6.6. From the measurements obtained after 24, 48 and 72 hours of stirring, the water solubility at 20°C was determined to be 10.8 g/L.