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Diss Factsheets
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EC number: 945-327-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study report from year 1974.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Reliability as reported in OECD SIDS (2004).
Data source
Reference
- Reference Type:
- other: Collection of data from published literature and company data.
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
- Principles of method if other than guideline:
- A cytogenetic assay on human embryonic lung cells (Wi-38) was performed. Mutations were quantified by counting anaphase aberrations. No metabolic activation.
- GLP compliance:
- no
- Type of assay:
- other: Cytogenetic assay on human embryonic lung cells (Wi-38). Mutations quantified by counting anaphase aberrations.
Test material
- Reference substance name:
- Silicic acid, calcium salt
- EC Number:
- 215-710-8
- EC Name:
- Silicic acid, calcium salt
- Cas Number:
- 1344-95-2
- Molecular formula:
- CaO3Si
- IUPAC Name:
- Silicic acid, calcium salt
Constituent 1
- Specific details on test material used for the study:
- Silene, synthetic amorphous calcium silicatel, hydrated, CAS 1344-95-2.
Method
Species / strain
- Species / strain / cell type:
- other: human embryonic lung cells (Wi-38)
- Metabolic activation:
- not specified
- Test concentrations with justification for top dose:
- Test concentrations used were 1, 10 and 100 µg/ml.
- Vehicle / solvent:
- Not specified.
Controlsopen allclose all
- Remarks:
- Not specified.
- Untreated negative controls:
- yes
- Remarks:
- 0.85 % saline
- Positive controls:
- yes
- Remarks:
- 0.1 µg/l triethylene melamine
Results and discussion
Test results
- Key result
- Species / strain:
- other: Human embryonic lung cells (Wi-38)
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Remarks:
- Anaphase aberrations
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Results from a cytogenetic assay with human embryonic lung cells, indicated no genotoxicity in vitro for synthetic amorphous calcium silicate.
- Executive summary:
The genotoxic potential of synthetic amorphous calcium silicate was tested in a cytogenetic assay with human embryonic lung cells (Wi-38). Mutations were quantified by counting anaphase aberrations. No genotoxicity in vitro for synthetic amorphous calcium silicate was indicated.
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