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EC number: 310-231-1 | CAS number: 140203-21-0 The distillate from the fractional distillation of high-temperature coal tar having an approximate distillation range of 280°C to 450°C (536°F to 842°F). Composed primarily of tri- and polynuclear aromatic hydrocarbons.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No particular irritation to skin and eye was
noted in experimental standard studies with the read-across source,
coal-tar pitch (CTPht). The same holds for the target compound,
Distillates (coal tar), high-temperature, heavy oils (EC no. 310-231-1;
CAS no. 140203-21-0), based on the similarity of composition.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 83/467/EEC
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Electrode binder [CAS No. 65996-93-2]
- Name of test material (as cited in study report): 101.110
- Physical state: solid, black powder - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harald Schriever, Kaninchenfarm, Bremerförde/Germany
- Age at study initiation: no data
- Weight at study initiation: 2.4 - 2.8 kg
- Housing: cage, single
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: >= 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +-2 °C
- Humidity (%): 50 - 86 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 / 12
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- readings: 1 h, 24, 48, and 72 h after removal of the cover
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- skin intact and scarified
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lukewarm water
- Time after start of exposure: 4 h
SCORING SYSTEM: according to Draize - Irritation parameter:
- other: erythema and edema score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- both on the intact and scarified skin
- Irritant / corrosive response data:
- There was no skin reaction over the observation time of 72 h (score 0 for all parameters).
- Interpretation of results:
- GHS criteria not met
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The target compound, Distillates (coal tar), high-temperature, heavy oils (EC no. 310-231-1; CAS no. 140203-21-0) as well as the read-across (source) compound, pitch (coal tar) [CAS No. 65996-93-2] are coal tar-borne UVCB substances consisting of a complex mixture of polycyclic aromatic hydrocarbons (PAH), predominantly of condensed four to five-ring aromatic ring systems which form a matrix that is practically insoluble in water. The GC-analytical profiles are very similar, and hence will be the physico-chemical and toxicological properties of these structure-related fractions. It is expected that the mammalian systemic and local toxicity of the target compound will not be higher than that of the read-across compound, pitch (coal tar).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The read-across (source) compound, pitch (coal tar), as heavy coal-tar distillate, shows a very similar PAH-profile: This is due to the fact that the considered coal-tar pitch is the high-molecular, "heavy" RESIDUE of a sequential fractionation procedure of coal tar with the temperature increasing, among others under vacuum distillation. On the other hand, the target compound is the high-termperature re-distillate of a high-molecular, heat-treated coal-tar fraction. This is expressed also in the respective fractions of total analysable GC-volatiles which amount to approx. 10% in coal-tar pich, while the GC volatiles of the target compound sum up to a comparable percentage of 13%.
3. ANALOGUE APPROACH JUSTIFICATION
By far the major part of the highly condensed matrix of Distillates (coal tar), high-temperature, heavy oils (EC no. 310-231-1; CAS no. 140203-21-0) is supposed to be biologically unavailable, as is pitch (coal tar ), the read-across source. This means, both mammalian toxicological profiles are supposed to closely overlap. - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across to preceding entry:
Source test material: Pitch (coal tar), high temperature [CAS no. 65996-93-2]
Reference: Sterner/IBR 1987_skin irritation - Irritation parameter:
- other: erythema and edema score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- both on the intact and scarified skin
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 83/467/EEC.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Electrode binder [CAS No. 65996-93-2]
- Name of test material (as cited in study report): 101.110
- Physical state: solid, black powder - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harald Schriever, Kaninchenfarm, Bremerförde/Germany
- Age at study initiation: no data
- Weight at study initiation: 2.4 - 2.6 kg
- Housing: cage, single
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: >= 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +-2 °C
- Humidity (%): 50 - 86 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 / 12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg - Observation period (in vivo):
- 1, 24, 48, and 72 h post-application
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no, eye not rinsed
SCORING SYSTEM: according to Draize
TOOL USED TO ASSESS SCORE: fluorescein after 24 and 72 h - Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 - #5
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #3, #4
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- animal: #2, #5, #6
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritant / corrosive response data:
- No irritation effects after 24 h (scores 0)
- Interpretation of results:
- GHS criteria not met
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The target compound, Distillates (coal tar), high-temperature, heavy oils (EC no. 310-231-1; CAS no. 140203-21-0) as well as the read-across (source) compound, pitch (coal tar) [CAS No. 65996-93-2] are coal tar-borne UVCB substances consisting of a complex mixture of polycyclic aromatic hydrocarbons (PAH), predominantly of condensed four to five-ring aromatic ring systems which form a matrix that is practically insoluble in water. The GC-analytical profiles are very similar, and hence will be the physico-chemical and toxicological properties of these structure-related fractions. It is expected that the mammalian systemic and local toxicity of the target compound will not be higher than that of the read-across compound, pitch (coal tar).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The read-across (source) compound, pitch (coal tar), as heavy coal-tar distillate, shows a very similar PAH-profile: This is due to the fact that the considered coal-tar pitch is the high-molecular, "heavy" RESIDUE of a sequential fractionation procedure of coal tar with the temperature increasing, among others under vacuum distillation. On the other hand, the target compound is the high-termperature re-distillate of a high-molecular, heat-treated coal-tar fraction. This is expressed also in the respective fractions of total analysable GC-volatiles which amount to approx. 10% in coal-tar pich, while the GC volatiles of the target compound sum up to a comparable percentage of 13%.
3. ANALOGUE APPROACH JUSTIFICATION
By far the major part of the highly condensed matrix of Distillates (coal tar), high-temperature, heavy oils (EC no. 310-231-1; CAS no. 140203-21-0) is supposed to be biologically unavailable, as is pitch (coal tar ), the read-across source. This means, both mammalian toxicological profiles are supposed to closely overlap. - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across to preceding entry:
Source test material: Pitch (coal tar), high temperature [CAS no. 65996-93-2]
Reference: Sterner/IBR 1987_eye irritation - Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 - #5
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1 - #5
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritant / corrosive response data:
- No irritation effects after 24 h (scores 0)
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No particular irritation to skin and eye was noted in experimental standard studies.
However, in the presence of UV-light (UVA), photo-induced human skin irritation was observed under working and experimental conditions (Crow et al. 1961). Human exposure to pitch (identity not specified) within a working environment under bright sunlight resulted in skin irritation. In addition, the same pitch experimentally applied on the skin of human volunteers as chloroform solution caused pronounced skin irritation after radiation with UV-light (UVA). The composition of the pitch utilised may be somewhat different from the registration substance due to differences in production conditions and distillation temperature. Basic constituents and consequentially basic effects will be the same for both substances. Thus, it is justified to use this study (Crow et al. 1961) to indicate possible irritation effects of the target compound under UV-light irradiation.
Justification for classification or non-classification
No irritating effects have been observed after exposure to pitch, coal tar, high-temp., the read-across substance, under standard test conditions. Hence, classification for irritation/corrosion is not required for Distillates (coal tar), high-temperature, heavy oils (EC no. 310-231-1; CAS no. 140203-21-0).
Potential UV-light induced skin irritating effects (see above) are not taken into account for classification, as conditions causing this effect do not correlate to standard test procedures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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