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Diss Factsheets
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EC number: 947-942-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- Cited as Directive 92/69/EEC, C.1
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- In the original report mistakenly the CAS number of hexamethylene diisocyanate (822-06-0) was specified. The test, however, was carried out with Desmodur LD (batch 2. filling) and the correct CAS number is 26488-60-8. The purity was not specified.
- Analytical monitoring:
- no
- Details on sampling:
- Sampling schedule:
- Control: at 96 hours
- Test concentration: at 0 and 96 hours - Vehicle:
- no
- Details on test solutions:
- - To produce the only Water Accommodated Fraction (WAF) the test item was added to dilution water, treated with an ultra-turrax for 60 seconds and afterwards stirred for 24 h on a magnetic stirrer
- Undissolved particles were removed by filtration using a folded filter (pore size of 7-12 μm)
- pH value was measured to be 8.1. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Source : Bio International B.V. (Netherlands)
- Date supplied : 2000-08-28
- Holding water: synthetic freshwater according ISO standard
- Mortalities during acclimatisation period : <2 %
- Medication : none
- Mean standard length (n = 10) : 2.5 - 3.5 cm - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- No data
- Test temperature:
- 21.5 (after 96 hrs)
- pH:
- 7.7 (after 96 hrs)
- Dissolved oxygen:
- 8.7 mg/L (after 96 hrs)
- Salinity:
- n.a.
- Nominal and measured concentrations:
- A Water Accommodated Fraction (WAF) was used to test effects at a limit effective loading of 100 mg/L. No specific analysis was performed.
- Details on test conditions:
- - Test vessels: glass aquaria (300 mm x 135 mm x 200 mm) holding 5 L of test media
- Experimental design: 1 test concentration plus 1 control
- Number of test organisms:10 fish per test concentration
- Photoperiod: 16 h light: 8 h dark
- Temperature: 21.3 - 21.5 °C
- Aeration: yes
- Test item concentration/s: 100 mg/L
- Method of administration: direct weighing
- Medium renewal: none
- Criteria of effects: The criterion of death used in this study was the absence of response to physical stimulation. In addition to observations on mortality at 2, 24, 48, 72 and 96 hours, type and incidence of sub lethal effects compared with control fish were observed. - Reference substance (positive control):
- not required
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The results are expressed in terms of Lethal Loadings (LL).
- Sublethal observations / clinical signs:
A Water Accommodated Fraction (WAF) was used to test effects at a limit effective loading of 100 mg/L no specific analysis was performed.
- Validity criteria fulfilled:
- yes
- Remarks:
- mortality in the controls <10 % by the end of the test; dissolved oxygen concentration above 60 % of the air-saturation value throughout the exposure period; pH did not vary by more than 1 unit
- Conclusions:
- After 96 hrs a LL-50 of higher than 100 mg/L was determined. The result is expressed in terms of Lethal Loadings (LL). No toxic effects against Brachydanio rerio (scientific name: Danio rerio) were observed at a limit test concentration under exposure conditions.
- Executive summary:
A study was performed to assess the acute toxicity to Brachydanio rerio (scientific name: Danio rerio) under static conditions. The study was conducted in accordance with Council Regulation (EC) No 440/2008, Method C.1 'Acute toxicity for Fish' (2008) which is in most parts equivalent to the OECD Guideline for Testing of Chemicals No. 203 'Fish, Acute Toxicity Test' (1992). A group of ten fish of the recommended size was exposed to a limit test concentration of nominally 100 mg/L dissolved in dilution water. Auxiliaries used to prepare the test media were an ultrasonic turrax, a magnetic stirrer and a folded filter. Observations were made on the number of dead fish and the incidence of sub-lethal effects after 2, 24, 48, 72 and 96 hours of exposure. After 96 hrs a LL-50 of higher than 100 mg/L was measured. The result is expressed in terms of Lethal Loadings (LL). No toxic effects against Brachydanio rerio (scientific name: Danio rerio) were observed at a limit test concentration under exposure conditions.
This toxicity study is classified as acceptable and satisfies the guideline requirements for the acute Fish study.
Reference
Description of key information
No toxic effects against fish were observed at the limit of water solubility under exposure conditions (96 h-LL0 >= 100 mg/L). The results are expressed in terms of Lethal Loadings (LL) (Caspers, 2001).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
"Should read >100 mg/L"
A Water Accommodated Fraction (WAF) was used to test effects at a limit lethal loading of 100 mg/L and no specific analysis was performed.
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