Registration Dossier
Registration Dossier
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EC number: 217-533-1 | CAS number: 1879-09-0
Endpoint summary
Administrative data
Description of key information
Overall summary of all information
Additional information
Fish:
Acute:
50% lethal concentration
24-hour 50% lethal concentration (LC50): 2.9 mg/L (95% confidence limit: 2.3-3.8 mg/L),
48-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.3-4.7 mg/L),
72-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.0-4.0 mg/L),
96-hour 50% lethal concentration (LC50): 2.5 mg/L (95% confidence limit: 1.9-3.7 mg/L)
Non-GLP Supporting study:
96h LC50 >1.0 mg/l, <10 mg/l.
Chronic:
Endpoint: Hatch (mg/L)
NOEC ≥1.0
LOEC >1.0
EC10 N.D.
EC20 N.D.
EC50 N.D.
N.D. = Not determined
Endpoint: Survival (post-hatch) (mg/L)
NOEC ≥1.0
LOEC >1.0
EC10 N.D.
EC20 N.D.
EC50 N.D.
N.D. = Not determined
Endpoint: Growth (length) (mg/L)
NOEC 0.32
LOEC 1.0
EC10 >1.0
EC20 >1.0
EC50 >1.0
Endpoint: Growth (wet weight)(mg/L)
NOEC 0.32
LOEC 1.0
EC10 0.493
EC20 0.931
EC50 >1.0
Endpoint: Growth (dry weight)(mg/L)
NOEC 0.32
LOEC 1.0
EC10 0.507
EC20 0.977
EC50 >1.0
The overall NOEC, based on nominal concentrations of 6-tert-butyl-2,4-xylenol at Day 28 post-hatch was therefore 0.32 mg/L.
Daphnia:
Acute
Result after 24 hours
50% effective inhibitory concentration (EC50): > 10 mg/L. The highest concentration causing 0% immobility: 2.1 mg/L. The lowest concentration producing 100 % immobility: > 10 mg/L
Result after 48 hours
50% effective inhibitory concentration (EC50): 2.9 mg/L (95% confidence limit: 2.5-3.4 mg/L). The highest concentration causing 0% immobility: 1.5 mg/L. The lowest concentration producing 100 % immobility: 10 mg/L
Chronic:
The results for this study are taken from the SIDS Initial Assessment Report, For SIAM 4, Tokyo, Japan, 20-22 May 1996, as the full report was not able to be located. The results are considered reliable as a data source used to support the SIDs programme; results collaborate with acute results that could be located. The full report is available at
http://www.inchem.org/documents/sids/sids/1879090.pdf.
As the lowest chronic toxicity result, the 21 d-NOEC (reproduction) of Daphnia magna (0.32 mg/l) was adopted.
Algae:
50% growth inhibition concentration ErC50 (0-48): 5.4 mg/L (95% confidence limit: 5.0-5.9 mg/L)
Maximum no effect concentration NOEC (Rate 0-48): 0.40 mg/L
50% growth inhibition concentration ErC50 (0-72): 6.0 mg/L (95% confidence limit: 5.3-6.6 mg/L)
Maximum no effect concentration NOEC (Rate 0-72): 0.38 mg/L
Micro-organisms:
EC50 (3 hour contact time) >10 mg/l.
On the basis of the results noted in the study, classification under the CLP Regulation (EC No 1272/2008 is as follows:
Chronic aquatic toxicity, Category 2; H411: Toxic to aquatic life with long lasting effects.
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