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Diss Factsheets
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EC number: 947-976-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not acutely toxic
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978 June - October
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- Test performed by nationally accredited lab with well-defined protocol.
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.40
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: NL Industries
- Expiration date of the lot/batch: Lot # 60-8313-01
- Purity test date: N/A
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Not reported
- Stability under test conditions: Assumed to be stable
- Solubility and stability of the test substance in the solvent/vehicle: N/A
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Used as received
- Preliminary purification step (if any): None
- Final dilution of a dissolved solid, stock liquid or gel: N/A
- Final preparation of a solid: N/A
FORM AS APPLIED IN THE TEST (if different from that of starting material) : 5000 mg/kg
TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable) : N/A
OTHER SPECIFICS: - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Summit View Farms, Belvidere, New Jersey
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: Not reported
- Weight at study initiation: 200-300 g
- Fasting period before study: 18 hr
- Housing: N/A
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: Not reported, To: 1978-08-29 - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE: N/A, Substance was used as received
MAXIMUM DOSE VOLUME APPLIED: Not reported
DOSAGE PREPARATION (if unusual): N/A
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Initially and at termination of the study
- Necropsy of survivors performed: Yes
- Other examinations performed: Gross organ pathology at the end of post-dosing observation period. - Statistics:
- N/A
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- No clinical signs
- Body weight:
- Normal weight gain
- Gross pathology:
- No changes in gross pathology
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was evaluated for acute oral toxicity according to 16 CFR 1500.40. The test substance was observed to be non-toxic in Sprague-Dawley rats at doses up to 5000 mg/kg.
Reference
Observation period (N = Normal)
0 -1 hr | 1 -3 hr | 3 -6 hr | 6 -24 hr | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 -14 | Cumulative |
10N | 10N | 10N | 10N | 10N | 10N | 10N | 10N | 10N | 10N | 10N |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978 June-October
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- Test performed by nationally accredited lab with well-defined protocol.
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.40
- Principles of method if other than guideline:
- - Principle of test:
To determine the lethality of the test material when applied to the skin of rabbits.
- Short description of test conditions: Test material is applied to either intact or abraded skin of the rabbit, and wrapped in an occluded bandage for 24 hours. Animals were observed for toxicity for 14 days thereafter.
- Parameters analysed / observed: Mortality, overt signs of toxicity, gross organ pathology (necropsy/autopsy), weight changes. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:
NL Industries
- Expiration date of the lot/batch:
Lot # 60-8313-01
- Purity test date:
N/A
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
Not reported
- Stability under test conditions: Assumed to be stable
- Solubility and stability of the test substance in the solvent/vehicle:
N/A
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium:
N/A
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
Used as received
- Preliminary purification step (if any):
None
- Final dilution of a dissolved solid, stock liquid or gel:
N/A
- Final preparation of a solid:
N/A
FORM AS APPLIED IN THE TEST (if different from that of starting material)
: N/A
TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable)
: N/A
OTHER SPECIFICS: - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Summit View Farms, Belvidere, New Jersey, USA
- Age at study initiation: Not reported
- Weight at study initiation: 2.3-3 kg
- Housing: Individually housed
- Diet (e.g. ad libitum): Ad libitum Purina Rabbit Chow
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: To: Not reported - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- % coverage: Not reported
- Type of wrap if used: non-reactive heavy gauge plastic, covered with opaque wrapping
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not reported (test material gently wiped off)
- Time after start of exposure: 24 hr
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg
- Concentration (if solution): N/A
- Constant volume or concentration used: yes
- For solids, paste formed: N/A
VEHICLE
- Amount(s) applied (volume or weight with unit): N/A
- Concentration (if solution): N/A
- Lot/batch no. (if required): N/A
- Purity: N/A - Duration of exposure:
- 24 hr
- Doses:
- 1
- No. of animals per sex per dose:
- 5 (2 animals of each sex were abraded, 3 animals of each sex were not abraded)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Initial, termination
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: irritation (erythema and edema) - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- 4 animals exhibited diarrhea during the window of 6 hr - 3 days post-exposure.
- Body weight:
- No major changes observed
- Gross pathology:
- No abnormal pathology observed. Irritation was noted at the application sites.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was evaluated under the criteria defined by 16 CFR 1500.40 for acute dermal toxicity in vivo. The test substance was determined to be non-toxic via the dermal route at exposure doses up to 2000 mg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
The test material was evaluated for in vivo oral and dermal acute toxicity. The test material was observed to be orally non-toxic in doses up to 5000 mg/kg bw and dermally non-toxic in doses up to 2000 mg/kg bw. GHS criteria (Regulation EC No. 1272/2208) for classification as acutely toxic are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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