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EC number: 265-929-8 | CAS number: 65799-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- [3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane
- EC Number:
- 220-780-8
- EC Name:
- [3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane
- Cas Number:
- 2897-60-1
- Molecular formula:
- C11H24O4Si
- IUPAC Name:
- Diethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane
- Reference substance name:
- [3-(2,3-epoxypropoxy)propyl]diethoxy(methyl)silane
- IUPAC Name:
- [3-(2,3-epoxypropoxy)propyl]diethoxy(methyl)silane
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: B&K Universal Ltd., Hull, Uk
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 15-23 g
- Housing: individually housed
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-20
- Humidity (%): 30-70
- Air changes (per hr): ca. 15
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- undiluted
25% or 50% v/v in acetone/olive oil 4:1 - No. of animals per dose:
- 4 animals per test group
- Details on study design:
- The mice were treated by application of 25 microlitres of the appropriate concentration of the test material to the dorsal surface of each ear for three consecutive days (days 0, 1, 2). A further group of 4 mice received the vehicle alone in the same manner.
Five days following the first topical application of the test material (day 5) all mice were injected via the tail vein with 250 microlitres of phosphate buffered saline containing a radiolabel. Five hours after that, all mice were killed. The draining auricular lymph nodes from the four mice were excised and pooled for each experimental group.
The proliferation response of lymph node cells was expressed as the number of radioactive disintegrations per minute per lymph node, relative to that recorded for control nodes.
If a threefold increase compared to control values was recorded, the substance was considered a sensitiser. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- The positive control substance (25% hexyl cinnamic aldehyde in acetone/olive oil 4:1) was considered to be a sensitiser in a study conducted in March 2003.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 0.9
- Test group / Remarks:
- 25% v/v; 4 mice, strain CBA/Ca
- Parameter:
- SI
- Value:
- 3.6
- Test group / Remarks:
- 50% v/v; 4 mice, strain CBA/Ca
- Parameter:
- SI
- Value:
- 4.6
- Test group / Remarks:
- 100% v/v; 4 mice, strain CBA/Ca
- Parameter:
- SI
- Value:
- 5.5
- Test group / Remarks:
- The positive control substance was considered to be a sensitiser in a study conducted in March 2003
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: see Remark
- Remarks:
- Vehicle 8425.12 Dpm, 1053.1 Dpm/node 25% 7802.73 Dpm 975.3 Dpm/node (negative) 50% 30366.88 Dpm 3795.8 Dpm/node (positive) 100% 39088.36 Dpm 4886 Dpm/node (positive)
Any other information on results incl. tables
A stimulation index of >3 was recorded for the two higher concentrations of test material (50% v/v and 100%). A stimulation index of <3 was recorded for the lowest concentration of the test material (25% v/v). There were no deaths. No signs of systemic toxicity were noted in the test or control animals during the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- The test material was considered to be a sensitiser under the conditions of the test. A stimulation index of >3 was recorded for the two higher concentrations of test material (50% v/v and 100%), relative to the negative controls.
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