Registration Dossier
Registration Dossier
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EC number: 234-634-6 | CAS number: 12018-10-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Existing toxicokinetic studies show that trivalent chromium (in contrast to hexavalent chromium) is poorly absorbed and taken up by cells when not organically complexed, such as in the glucose tolerance factor. Less than 1% of chromium III is absorbed from the normal diet, inhaled chromium III uptake is a very slow process, and chromium III compounds were not shown to be absorbed across the skin into systemic circulation. The prominent tissues of chromium distribution are the liver, kidneys and spleen as well as bone and the remaining carcass (muscle, skin and hair). There is no clear evidence to show the valency of trivalent chromium changes during metabolism and chromium III is mainly excreted in the urine and to a lesser extent in the faeces.
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