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EC number: 247-744-4 | CAS number: 26495-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 13 - Aug 02, 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- October 2000
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 454-780-6
- EC Name:
- -
- Cas Number:
- 27445-54-1
- Molecular formula:
- Hill formula: C12H27NO2Si CAS formula: C12H27NO2Si
- IUPAC Name:
- Cyclohexyl-((diethoxy-methyl-silanyl)-methyl)-amine
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Since the test item hydrolyses in water very quickly, in the present test the hydrolysis products of the test item were tested, according to the draft guidance document on aquatic toxicity testing of difficult substances. Therefore, 315 mg test item were mixed into 1500 mL test water by intense stirring for 24 hours. Then, adequate volumes of the intensively stirred solution of the test medium will be mixed into test water to obtain the desired test concentrations.
The test media were prepared just before introduction of Daphnia (= start ofthe test).
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Age at test start:
- 7 hours and 30 minutes to 23 hours and 15 minutes old
- females
Origin:
- supplied 1997 by the Umweltbundesamt, Institut fUr Wasser-, Boden- und Lufthygiene, Berlin, Germany
Breeding conditions:
- The Daphnia were bred in the laboratories of IBACON under similar temperature and light conditions as in the test, and in reconstituted water of a similar quality regarding to pH, components of the main ions and total hardness as the test water used in the test (see below). The test organisms were not fIrst brood progeny. The Daphnia of the stock culture were fed at least each working day with green algae (Desmodesmus subspicatus) freshly grown in the laboratories ofIBACON.
Toxic Standard:
- For the evaluation of the quality of the Daphnia clone and the experimental conditions the substance potassium dichromate p.A. is tested at least twice a year to demonstrate satisfactory test conditions.
Acclimatisation:
- for 7 hours and 30 minutes under test conditions
Study design
- Test type:
- static
- Water media type:
- other: Reconstituted Water (Elendt "M4") with a Hardness of 2.5 mmol/L (= 250.0 mgIL) as CaC03
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 2.5 mmol/L (= 250.0 mg/L) as CaC03
- Test temperature:
- 20°C
- pH:
- 7.0 -7.6
- Dissolved oxygen:
- At the end of the test the dissolved oxygen concentration in the test media was >= 2 mg O2/L in the control and test vessels.
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal 11, 23, 48, 100 and 210 mg test item/L and a control
Mean Recovery in the Test Samples:
after 0 h: 86 % (n = 10, SD 2 %)
after 48 h: 82 % (n = 10, SD 4 %)
The analytically determined mean test item concentrations in the analysed test media varied in the range from 81 % to 87 % of the nominal values. In the test media the test item was sufficiently stable during the test period of 48 hours. Therefore, all reported biological results are related to the
nominal concentrations of the test item. - Details on test conditions:
- Test Units:
- glass beakers of 100 mL volume with 80 mL test medium
- Each test unit was uniquely identifIed with study number,treatment and replicate number.
Test conditions:
- controlled environment room
- Light Regime: 16 h light: 8 h dark
- Light Intensity: 150 - 420 lux
Introduction of individuals:
- 20 Daphnia per control and test concentration, divided into 4 groups of 5 animals, each group in 80 mL test medium
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 210 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: test mat. / but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 48 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: test mat. / but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- After 48 hours in the control and in the test concentrations up to 48 mg test item/L no mortality or immobilization of the test animals was observed and in the test concentrations 100 and 210 mg/L mortality or immobilization was statistically significantly affected compared to the control. The immobilization rate was 10.0 and 35 % in the 100 and 210 mg test item/L treatment groups, respectively.
Table 2). The 48-hour EC 50 and the 48-hour EC 100 of
Geniosil210 mg test item/L. These values could not be quantified,
since concentrations in excess of 210 mgIL have not been
tested.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-hour EC50 value of >210 mg/L and a NOEC of 48 mg/L have been determined for the effects of the test substance on mobility of Daphnia magna based on nominal exposure concentrations of the substance. The test substance hydrolyses in water and it is therefore likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
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