Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-192-0 | CAS number: 1112-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2017-09-05 to 2017-11-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetravinylsilane
- EC Number:
- 214-192-0
- EC Name:
- Tetravinylsilane
- Cas Number:
- 1112-55-6
- Molecular formula:
- C8H12Si
- IUPAC Name:
- tetraethenylsilane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Lot number: 707001
Purity: 98.6%
Appearance: Colourless tranparent liquid
Storage conditions: Refrigerator (1-10°C) in an air-tight container
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Source: Charles River Laboratories, Japan (Hino Breeding Center)
Age of animals on receipt: Seven weeks
Quarantine/acclimatisation period: Seven days
Age at time of administration: Eight weeks (first and second step; 300 mg/kg bw); Nine weeks (third and fourth step; 2000 mg/kg bw).
Body weight at time of administration: 189.6-195.0g (first step; 300 mg/kg bw dosing); 188.1-195.1g (second step; 300 mg/kg bw dosing); 195.7-203.8g (third step; 2000 mg/kg bw dosing); 186.8-192.4g (fourth step; 2000 mg/kg bw)
Temperature: 21-25°C
Relative humidity: 40-70%
Air changes: 10-15/hour
Photoperiod: 12 hours light/dark cycle
Caging: Stainless steel cages with mesh floor
Housing: Up to 3/cage during acclimatisation; Individual until dosing
Feed: Pellet diet (MF; Oriental Yeast); ad libitum
Water: Chlorinated water (chlorine at 3-5 ppm) by adding sodium hypochlorite to Hita City mains supply; ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Concentration of dosing formulation: 3.00% w/v (300 mg/kg bw); 20.0% w/v (2000 mg/kg bw)
Dosing volume: 10 mL/kg bw
Rationale for dosing: No toxicity data available therefore first step was 300 mg/kg bw
Animals fasted for 18-19 hours before administration and for 3-4 hours after administration
Dosing based on body weight measured on the day of dosing - Doses:
- 300 mg/kg bw (first and second step)
2000 mg/kg bw (third and fourth step) - No. of animals per sex per dose:
- Three females/dose for each step
- Control animals:
- no
- Details on study design:
- Animals dosed with 300 mg/kg bw for the first and second steps were observed continuously for 10 minutes after dosing, 30 minutes and 3 hours after administration and then daily from 1 to 14 days after administration.
Animals dosed with 2000 mg/kg bw for the third and fourth steps were observed continuously for 10 minutes after dosing, 30 minutes, 1, 3 and 5 hours after administration and once on the morning after dosing. Additional observations in the evening were performed the day after dosing for the thirs step and for the first two days after dosing for the fourth step.
Body weights were measured before administration, then 1, 7 and 14 days after dosing.
Animals were subjected to a gross necropsy 14 days after dosing.
Animals were euthanised by bleeding from the abdominal aorta under isoflurane anaesthesia. External surface of the body, all orifices, subcutis, cranial, thoracic, abdominal and pelvic cavities with their contents were observed. - Statistics:
- Not required.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Mortality:
- No mortalities or moribundities for any treatment.
- Clinical signs:
- other: At 300 mg/kg bw, mucus stools were observed in four animals 30 minutes or 3 hours after dosing. This finding was attibuted to the effect of the vehicle since this was not dose dependent and historical data show this has occured in 38/135 females following
- Gross pathology:
- No abnormalities were observed at 300 or 2000 mg/kg bw.
- Other findings:
- None
Any other information on results incl. tables
Clinical signs
Clinical sign |
Dose group |
|||
300 mg/kg bw (first step) |
300 mg/kg bw (second step) |
2000 mg/kg bw (third step)
|
2000 mg/kg bw (fourth step)
|
|
Salivation |
0/3 |
0/3 |
0/3 |
1/3 |
Mucus stool |
1/3 |
3/3 |
0/3 |
0/3 |
Decreased stool volume |
0/3 |
1/3 |
0/3 |
0/3 |
Decreased spontaneous locomotion |
0/3 |
0/3 |
3/3 |
3/3 |
Decreased respiratory rate |
0/3 |
0/3 |
3/3 |
3/3 |
Incomplete eyelid opening |
0/3 |
0/3 |
3/3 |
3/3 |
Restlessness |
0/3 |
0/3 |
1/3 |
1/3 |
Lacrimation |
0/3 |
0/3 |
0/3 |
1/3 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not classified
- Conclusions:
- The LD50 cut off value of test item defined as 5000 mg/kg bw or unclassified since no mortalities or moribundities occurred at 2000 mg/kg bw.
- Executive summary:
A GLP compliant study was conducted to determine acute oral toxicity of test item according to OECD 423. Three female Crl: CD (SD) rats were initially administered with 300 mg/kg bw. Since no mortalities or moribundities were observed, a further group of three females were dosed with 300 mg/kg bw. Since the findings in this additonal group were consistent with the first treatment group, the dose was increased to 2000 mg/kg bw for a further group of three females. Since no mortalities or moribundities were observed in this group, a further three females were dosed with 2000 mg/kg bw. Clinical signs were observed continuously for the first 10 minutes, then at longer intervals up to 5 hours after dosing and at least once daily up to the end of the observation period of 14 days following test substance administration. Body weight was recorded throughout. The animals were then subject to gross necropsy. External surface of the body, all orifices, subcutis, cranial, thoracic, abdominal and pelvic cavities with their contents were examined. No mortalities or moribundities were observed. A slight decrease in body weight gain was noted in two animals dosed with 2000 mg/kg bw one day after administration. There were no clinical signs at 300 mg/kg bw. At 2000 mg/kg bw, decreased spontaneous locomotion was observed in all six animals from 30 minutes after dosing which persisted until one or two days after administration. Decreased respiratory rate and incomplete eyelid opening was also noted in all six animals within 1 hour of dosing which persisted until the following day for only the second group dosed with 2000 mg/kg bw. Salivation was observed in one animal 30 minutes after administration. Restlessness was noted in two animals and lacrimation in one animal 1 hour after dosing. No other abnormalities were observed three days after dosing or for the remaining observation period for the higher dose animals. No abnormalities were noted during gross necropsy. The LD50 cut off value of test item defined as 5000 mg/kg bw or unclassified since no mortalities or moribundities occurred at 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)