Registration Dossier
Registration Dossier
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EC number: 203-613-3 | CAS number: 108-75-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Prehled Prumyslove Toxikologie; Organicke Latky, Prague, Czechoslovakia, Avicenum, Pg. 841, 1986. (2,4,6-Collidine)
- Author:
- Marhold, J
- Year:
- 1 986
- Bibliographic source:
- https://chem.nlm.nih.gov/chemidplus/number/startswith/108-75-8
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Version / remarks:
- Data cited in ChemIDplus database.
- Principles of method if other than guideline:
- Data cited in ChemIDplus database. Only result is provided on the database.
- GLP compliance:
- not specified
- Test type:
- other: No information available from data source.
Test material
- Reference substance name:
- 2,4,6-trimethylpyridine
- EC Number:
- 203-613-3
- EC Name:
- 2,4,6-trimethylpyridine
- Cas Number:
- 108-75-8
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2,4,6-trimethylpyridine
Constituent 1
- Specific details on test material used for the study:
- No specific details on test material used for the study is provided.
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No other information from the data source.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No other information from the data source.
- Duration of exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No other information from the data source.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: Data obtained from an authoritative secondary source (only LD50 value provided).
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 of guinea pig is found to be 1000 mg/kg through dermal administration of 2,4,6-collidine.
- Executive summary:
The LD50 of guinea pig is found to be 1000 mg/kg through dermal administration of 2,4,6-collidine.
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