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Diss Factsheets
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EC number: 947-687-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-3-(dodecyloxy)propan-2-ol
- EC Number:
- 241-661-7
- EC Name:
- 1-chloro-3-(dodecyloxy)propan-2-ol
- Cas Number:
- 17677-15-5
- Molecular formula:
- C15H31ClO2
- IUPAC Name:
- 1-chloro-3-(dodecyloxy)propan-2-ol
- Test material form:
- liquid
- Details on test material:
- pale straw/yellow liquid
Constituent 1
- Specific details on test material used for the study:
- Study was performed long before substance identity was confirmed in detail. It is hence very plausible that this study has not been conducted on 1-chloro-2-hydroxy-3-(n-dodecoxy)propane, but on the registered substance 'Reaction mass of 1-chloro-3-{[1-chloro-3-(dodecyloxy)propan-2-yl]oxy}propan-2-ol and 1-chloro-3-(dodecyloxy)propan-2-ol'. In this view, the study was found relevant for this registration.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles Rivers UK
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 6 to 7 weeks
- Weight at study initiation: 183 to 222 g (males) and 131 to 192 g (females)
- Housing: housed on grids
- Diet (e.g. ad libitum): commercially available standard 17% rat/mouse pelleted diet - ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-25°C
- Humidity (%): 34-80 %
- Photoperiod (hrs dark / hrs light): 12 h light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Remarks:
- for the diluted administrations only
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Not specified
- Amount of vehicle (if gavage): 1 mL/100 g body weight
MAXIMUM DOSE VOLUME APPLIED: 10,000 mg/kg bw
- Rationale for the selection of the starting dose: range finding study performed at 10,000 mg/kg bw - Doses:
- 2000, 5000 and 10,000 mg/kg bw
- No. of animals per sex per dose:
- 5 per sex and per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 20 to 40 minutes post dosing and 1,2,3 and 4 hours post dosing, and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Statistics:
- not necessary
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Only 1 death in the high dose group - no gross abnormalities were observed at post-mortem examination.
- Clinical signs:
- No abnormal signs were reported in the low dose group (2000 mg/kg bw). In the intermediate group a decrease in activity was observed at start, but after 4 days no abnormal signs observed. In the higher dose groupthe decrease in activity was more important. Moreover, the body coats appeared oily.
- Body weight:
- Normal weight gain was observed.
- Gross pathology:
- Only abnormalities seen at end (14 days) in necropsies was for female rats (high dose): stomach slightly compacted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance appears not to be toxic via oral route, with an LD50 value of > 10,000 mg/kg bw for females and males.
- Executive summary:
An acute oral toxicity study has been performed on 1 -chloro-2 -hydroxy-3 -(N-dodecoxy) propane, according to OECD 401 (1987) and Method B.1 of 92/69/EEC.
Oral toxicity to Sprague Dawley CD rats following single dose administration via oral gavage in corn oil to 4 groups of 10 rats (5 male and 5 female per group) was assessed. The administered doses were: control, 2000, 5000 and 10,000 mg/kg bodyweight. During the main study, one female rat died at the highest dose on day 9. Animals treated with 10,000 mg/kg bw had slightly oily coats. All animals showed decrease in activity. Necropsis at day 14 showed that the females dosed with 10,000 mg/kg bw had sightly compacted stomach.
The LD50 was found to be >10,000 mg/kg bw (females, males and combined).
Study was performed long before substance identity was confirmed in detail. It is hence very plausible that this study has not been conducted on 1-chloro-2-hydroxy-3-(n-dodecoxy)propane, but on the registered substance 'Reaction mass of 1-chloro-3-{[1-chloro-3-(dodecyloxy)propan-2-yl]oxy}propan-2-ol and 1-chloro-3-(dodecyloxy)propan-2-ol'. In this view, the study was found relevant for this registration.
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