Registration Dossier
Registration Dossier
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EC number: 204-611-5 | CAS number: 123-23-9
Endpoint summary
Administrative data
Description of key information
96 h, LC50 (Danio rerio): >73 mg/L (geometric mean measured concentration)
48 h, EC50 (Daphnia magna): 13 mg/L (geometric mean measured concentration)
96 h, EC50 (Desmodesmus subspicatus and Pseudokirchneriella subcapitata): 90.82 mg/L (predicted value)
Additional information
The endpoints Short-term toxicity to aquatic invertebrates and Short-term toxicity to fish were covered with read-across approch to the source substance 5-[(4-carboxybutanoyl)peroxy]-5-oxopentanoic acid, GAP (CAS 10195-54-7, EC 600-254-8).
Short-term toxicity to fish:
The acute toxicity of the test substance was evaluated with Zebrafish using a 96-hour static test according to OECD guideline No. 203 and EU method C.1. A preliminary test preceded the definitive test. Five concentrations of the test substance were used together with a control at: 4.6, 10, 22, 46 and 100 mg/L. 14 daphnids (in two replicates of seven) were exposed to each concentration for 96 hours and mortality and symptoms of intoxications were recorded at 3, 24, 48, 72 and 96 hours. Initial concentrations of the test item measured in the definitive test solutions were 67% till 73 % of the corresponding nominal values. Therefore, the reported biological results are related to the total mean measured test article concentrations: 3.2, 6.7, 15.6, 31 and 73 mg/L. Under the experimental conditions, the 96-hour LC50 of the test substance in a static test system is >73 mg/L for Zebrafish.
Short-term toxicity to aquatic invertebrates:
The acute toxicity of the test substance was evaluated with Daphnia magna STRAUS using a 48-hour static test according to OECD guideline No. 202 and EU method C.2. A preliminary test preceded the definitive test. Five concentrations of the test substance were used together with a control at: 4.6, 10, 22, 46 and 100 mg/L. Twenty daphnids (in two replicates of ten) were exposed to each concentration for 48 hours and immobilization was recorded at 0, 24 and 48 hours. Initial concentrations of the test item measured in the definitive test solutions were 69% till 82 % of the corresponding nominal values. Therefore, the reported biological results are related to the total mean measured test article concentrations: 3.6, 7.4, 17.6, 40 and 94 mg/L. Under the experimental conditions, the 48-hour EC50 of the test substance in a static test system is 13 mg/L (95% CI: 11 - 14 mg/L) for Daphnia magna.
Toxicity to aquatic algae:
The toxicity of the test item on algae was calculated using ECOSAR v 1.11 to be 90.82 mg/L.
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