Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 294-955-2 | CAS number: 91771-62-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cyperus scariosus, Cyperaceae.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance monograph of the test substance
- Author:
- D.L.J Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology, 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of the test chemical in humans
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Camphene
- EC Number:
- 201-234-8
- EC Name:
- Camphene
- Cas Number:
- 79-92-5
- Molecular formula:
- C10H16
- IUPAC Name:
- Camphene
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report):1,7,7-trimethylbicyclo[2.2.1]heptan-2-one- Molecular formula :C10H16- Molecular weight:136.236 g/mol- Substance type:Organic- Physical state:Solid
Constituent 1
Test animals
- Species:
- other: humans
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 4% in petrolatum
- Duration of treatment / exposure:
- 48 h
- Observation period:
- 48 h
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test chemical was not irritating to humans after 48 hours exposure
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The test chemical was not irritating to humans after 48 hours exposure
- Executive summary:
A skin irritation study was performed in humans to assess the irritation potential of the test chemical. The test chemical 4% in petrolatum was applied on the skin of human volunteers in a 48 hours closed patch test and observed for signs of irritation.
The test chemical was not irritating to humans after 48 hours exposure
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
