9,10-dioxoanthracene-2-carboxylic acid

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

effects on growth of green algae

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference

Reference Type:

other: QSAR-tool

Title:

Estimation Program Interface EPI Suite (TM) v4.11: ECOSAR v1.11

Author:

United States Environmental Protection Agency, Washington, DC, USA.

Bibliographic source:

http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm

Materials and methods

Principles of method if other than guideline:

The QSARs presented were developed by classification/sub-classification of chemicals based on similarity of structure and similarity in measured effect levels from aquatic toxicity data. When available, modes of action (MOA) have been integrated into the classification scheme to substantiate trends seen in available data. Although acute and chronic toxicity of chemicals to fish (both fresh and saltwater), aquatic invertebrates (freshwater daphnids and saltwater mysids), and algae (freshwater green algae and saltwater algae) has been the focus of QSAR development, additional QSARs for certain chemical classes were developed for other organisms (e.g., earthworms, sea urchins, and Lemna gibba).

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

124.221 mg/L

Any other information on results incl. tables

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ECOSAR v1.11 Class-specific Estimations

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******************************************************************************

| Not Related to an Existing ECOSAR Class Definition                        |

|                                                                           |

| Estimates provided below use the Neutral Organics QSAR equations which    |

| represent baseline toxicity potential (minimum toxicity) assuming a simple |

| non-polar narcosis model. Without empirical data on structurally similar |

| chemicals, it is uncertain if this substance will present significantly   |

| higher toxicity above baseline estimates.                                 |

******************************************************************************

 

Predicted

ECOSAR Class                Organism           Duration End Pt  mg/L (ppm)

=========================== ================== ======== ======  ==========

--> Acid moeity found: Predicted values multiplied by 10

 

Neutral Organics-acid     : Fish               96-hr    LC50     164.249 *

Neutral Organics-acid     : Daphnid            48-hr    LC50     104.438 *

Neutral Organics-acid     : Green Algae        96-hr    EC50     124.221 *

Neutral Organics-acid     : Fish                         ChV       18.348 *

Neutral Organics-acid     : Daphnid                      ChV       13.956 *

Neutral Organics-acid     : Green Algae                  ChV       41.856 *

Neutral Organics-acid     : Fish (SW)          96-hr    LC50     208.300 *

Neutral Organics-acid     : Mysid              96-hr    LC50      67.478 *

Neutral Organics-acid     : Fish (SW)                    ChV       47.794 *

Neutral Organics-acid     : Mysid (SW)                   ChV        4.056

Neutral Organics-acid     : Earthworm          14-day   LC50    3272.488 *

 

Note: * = asterisk designates: Chemical may not be soluble enough to

measure this predicted effect. If the effect level exceeds the

water solubility by 10X, typically no effects at saturation (NES)

are reported.

 

 

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Class Specific LogKow Cut-Offs

------------------------------

If the log Kow of the chemical is greater than the endpoint specific cut-offs

presented below, then no effects at saturation are expected for those endpoints.

 

Neutral Organics:

----------------

Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50, Mysid LC50)

Maximum LogKow: 6.0 (Earthworm LC50)

Maximum LogKow: 6.4 (Green Algae EC50)

Maximum LogKow: 8.0 (ChV)