Registration Dossier
Registration Dossier
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EC number: 240-968-3 | CAS number: 16919-19-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- no detailed information
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium hexafluorosilicate
- EC Number:
- 240-968-3
- EC Name:
- Ammonium hexafluorosilicate
- Cas Number:
- 16919-19-0
- Molecular formula:
- F6Si.2H4N
- IUPAC Name:
- diammonium hexafluorosilicate
- Test material form:
- solid: particulate/powder
1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Amount / concentration applied:
- 50 mg /eye
- Duration of treatment / exposure:
- 24 h
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not specified
- Basis:
- other: not specified
- Time point:
- 24 h
- Score:
- ca. 10
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- 3 h after appilction: cloudiness of cornea, edema of conjuctivae, exudate
24 h after application: eye completely covered with pus, after removing the pus revealed a damaged cornea, no visible macrostructures of the iris, dimensions of pupill not determinable
Index 10
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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