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EC number: 606-744-8 | CAS number: 213464-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The 96-hour LC50 value for the Rainbow trout fish exposed to IR5878 was greater than 122 mg/L, the highest concentration tested. No mortalities or toxic effects were observed in Rainbow trout exposed to IR5878 at concentrations up to 122 mg/L. The 96-hour no mortality concentration and the NOEC were 122 mg/L.
The 96-hour NOEC and the 96-hour LC0 of IR5878 to Zebra fish were determined to be at least 100 mg/L. The 96-hour LOEC , the 96-hour LC50 and the 96-hour LC100 were clearly higher than 100 mg/L.
The 96-hour LC50 value for the Bluegill fish exposed to IR5878 was greater than 142 mg/L, the highest concentration tested. No mortalities or toxic effects were observed in Bluegill exposed to IR5878 at concentrations up to 142 mg/L. The 96-hour no mortality concentration and the NOEC were 142 mg/L.
A study was performed to evaluate the influence of IR5878 on the mobility respectively survival ofDaphnia magna. Groups of 20 youngDaphnia magnawere exposed in a static test for 48 hours to an aqueous test medium containing IR5878 at concentrations of 0,12.5, 25, 50 and 100 mg/L. The 24-hour EC0of IR5878 was 50 mg/L. The 24-hour EC50of IR5878 were clearly higher than 100 mg/L. The 24-hour EC100of IR5878 were clearly higher than 100 mg/L. The 48-hour EC0of IR5878 was 50 mg/L. The 48-hour EC50of IR5878 were clearly higher than 100 mg/L. The 48-hour EC100of IR5878 were clearly higher than 100 mg/L. The NOEC of IR5878 was 50 mg/L.
A study was performed to evaluate the influence of IR5878 on survival of 3-4 days old larvae ofChironomus riparius. In a limit test 4 groups of 5 first instar larvae ofChironomus ripariuswere exposed to IR5878 at the nominal concentration of 100 mg/L for 48 hours. 4 additional groups of 5 animals where used as control. The 48-hour NOEC and EC0of IR5878 to the larvae ofChironomus ripariuswere determined to be at least 100 mg/L (the only tested concentration). The 48-hour LOEC and the 48-hour EC50were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of IR5878 up to the highest test concentration.
A study was performed to determine the toxicity of IR5878 to the red swamp crayfish (Procambarus clarkii) during a 96-hour exposure period under static test conditions. Crayfish were exposed to a geometric series of five test concentrations (7.5, 15, 30, 60 and 120 mg IR5878/L) and a negative (dilution water) control. The 96-hour LC50value for the Crayfish (Procambarus clarkii) exposed to IR5878 was greater than 129 mg/L, the highest concentration tested. No mortalities or effects were observed in Crayfish exposed to IR5878 at concentrations up to 129 mg/L. The 96-hour no mortality concentration and the NOEC were 129 mg/L. Measured tissue concentrations of IR5878 in the Crayfish ranged from below the LOQ up to 1.99 µg a.s./g.
A study was performed to determine the median lethal concentration (LC50) of IR5878 to pond snail (Lymnaea stagnalis). Based on the results of a range finding test, the definitive test was carried out at nominal concentrations of IR5878 of12.5, 25, 50 and 100 mg/L. The test was carried out under static conditions over a 96 hours period. The 96-hour LC50of IR5878 to pond snail was estimated to be > 100 mg/L and the 96-hour NOEC to be 100 mg/L, under the conditions of the test.
A study was performed to evaluate the inhibitory effect of IR5878 on the growth of the freshwater green algal speciesScenedesmus subspicatus. Groups of 3 parallel exponentially growing cultures were treated at the concentrations of 4.6, 10, 21, 46 and 100 mg/L and incubated in a water bath.EC50(biomass) was 41.4 mg/L. EC50(growth rate) was 87.1 mg/L. NOEC (72-h) for biomass and growth rate was 10 mg/L. LOEC (72-h) for biomass and growth rate was 21 mg/L.
A study was performed to evaluate the inhibitory effect of IR5878 on the growth of the freshwater blue algal speciesAnabaena flos-aquae. Groups of 3 parallel exponentially growing cultures were treated at the concentrations of 0.46, 1.0, 2.1, 4.6, 10 and 21 mg/L and incubated in a water bath. EC50(biomass) was 1.9 mg/L. EC50(growth rate) was 13.0 mg/L. NOEC (72-h) for biomass was mg/L. NOEC (72-h) for growth rate wasmg/L. LOEC (72-h) for biomass wasmg/L. LOEC (72-h) for growth rate was 0.79 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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