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EC number: 217-062-1 | CAS number: 1732-96-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 26 October 2017 Experimental completion date: 07 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: sieve screening followed by cascade impactor
- Type of particle tested:
- other: powder
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- Ethylene bis[1,3-dihydro-1,3-dioxoisobenzofuran-5-carboxylate]
- EC Number:
- 217-062-1
- EC Name:
- Ethylene bis[1,3-dihydro-1,3-dioxoisobenzofuran-5-carboxylate]
- Cas Number:
- 1732-96-3
- Molecular formula:
- C20H10O10
- IUPAC Name:
- 2-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyloxy)ethyl 1,3-dioxo-1,3-dihydro-2-benzofuran-5-carboxylate
- Reference substance name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
- EC Number:
- 209-008-0
- EC Name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
- Cas Number:
- 552-30-7
- Molecular formula:
- C9H4O5
- IUPAC Name:
- Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
- Reference substance name:
- not assignable
- IUPAC Name:
- not assignable
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Identification: RIKACID TMEG-500
CAS No.: 1732-96-3
Chemical name: Ethylene bis[1,3-dihydro-1,3-dioxoisobenzofuran-5-carboxylate]
Appearance/physical state: cream colored powder
Batch: 5259
Purity: 81.1%
Expiry date: 24 April 2018
Storage conditions: room temperature, in the dark
Results and discussion
- Remarks on result:
- not determinable
- Remarks:
- Too few particles were of a size less than 10.0 µm to allow accurate assessment of the mass median aerodynamic diameter.
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 34.1 %
- Remarks on result:
- other: Sieve Screening Test
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- <= 4.2 %
- Remarks on result:
- other: Cascade impactor
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- <= 0.8 %
- Remarks on result:
- other: Cascade impactor
Any other information on results incl. tables
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Measurement |
Result |
Mass of test item transferred to sieve |
17.21 g |
Mass of test item passed through sieve |
5.86 g |
Percentage of test item less than 100 µm |
34.1% |
Cascade Impactor
The results of the cascade impactor procedure are shown in the following table:
Collection stage |
Particle size range collected (µm) |
Collected mass (g) |
||
Determination 1 |
Determination 2 |
Determination 3 |
||
Artificial throat |
n/a |
0.16 |
0.12 |
0.07 |
Cup 1 |
>10.0 |
2.8413 |
2.7293 |
2.6823 |
Cup 2 |
5.5 to 10.0 |
0.0479 |
0.1015 |
0.0965 |
Cup 3 |
2.4 to 5.5 |
0.0020 |
0.0116 |
0.0157 |
Cup 4 |
1.61 to 2.4 |
0.0000 |
0.0028 |
0.0049 |
Cup 5 |
0.307 to 1.61 |
0.0000 |
0.0012 |
0.0022 |
Final filter |
<0.307 |
0.0003 |
0.0003 |
0.0012 |
Total mass of collected test item |
3.0515 |
2.9667 |
2.8728 |
|
Mass of test item added |
3.0941 |
3.0355 |
2.9757 |
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Particle size cut point (µm) |
Cumulative mass (g) |
Cumulative percentage (%) |
||||
Det 1 |
Det 2 |
Det 3 |
Det 1 |
Det 2 |
Det 3 |
|
<10.0 |
0.0502 |
0.1174 |
0.1205 |
1.6 |
4.0 |
4.2 |
<5.5 |
0.0023 |
0.0159 |
0.0240 |
0.1 |
0.5 |
0.8 |
<2.4 |
0.0003 |
0.0043 |
0.0083 |
<0.1 |
0.1 |
0.3 |
<1.61 |
0.0003 |
0.0015 |
0.0034 |
<0.1 |
0.1 |
0.1 |
<0.307 |
0.0003 |
0.0003 |
0.0012 |
<0.1 |
<0.1 |
<0.1 |
Overallcumulative percentage with a particle size less than 10.0 µm: ≤4.2%
Overallcumulative percentage with a particle size less than 5.5 µm: ≤0.8%
Discussion
Prior to sampling for the cascade impactor determinations,the test item containerwas rotated forapproximatelytenminutes,before taking aliquotsfrom the top, middle and bottomfor evaluation.
The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; thisgavea worst case scenario. Too few particles were of a size less than 10.0 µm to allow accurate assessment of the mass median aerodynamic diameter.
During cascade impactor analysis,determination 1,extremely minor apparent weight losses were recorded for sample cupsnumber 3 and 4 between pre-sample introduction and post-sample introduction weighings. However the magnitude of these deviations in the essentially empty sample cup weights were considered negligible, the largest being only1.4 mg. Critically, with only a total of 1.6% of the test item having been identified as having a particle size <10 µm during determination 1, the weight anomalies identified would have absolutely no influence on the overall limit value of≤4.2% for particles <10 µm reported for the test item.
The inhalable fraction is defined as the mass fraction of particles which may be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles thatmaypass the larynx and the respirable fraction is defined as the mass fraction of particles that may reach the alveoli.
Applicant's summary and conclusion
- Conclusions:
- Particle size data acquired for the test item is shown in the following table:
Percentage of test item with an inhalable particle size <100 µm - Sieve - 34.1%
Percentage of test item with a thoracic particle size <10.0 µm - Cascade impactor - ≤ 4.2%
Percentage of test item with a respirable particle size <5.5 µm - Cascade impactor - ≤ 0.8% - Executive summary:
Particle Size Distribution.Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002). The results are as follows:
Measurement
Method
Result
Proportion of test item having an inhalable particle size <100 µm
Sieve
34.1%
Proportion of test item having a thoracic particle size <10.0 µm
Cascade Impactor
≤4.2%
Proportion of test item having a respirable particle size <5.5 µm
Cascade Impactor
≤0.8%
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