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Reaction mass of Pentaerythritol bis (2-ethylhexanoate) bis (3,5,5-trimethylhexanoate) and Pentaerythritol tris (2-ethylhexanoate) 3,5,5-trimethylhexanoate and Pentaerythritol 2-ethylhexanoate tris (3,5,5-trimethylhexanoate) and Pentaeryhthritol tetrakis(2-ethylhexanoate) and Pentaerythritol tetrakis (3,5,5-trimethylhexanoate)
EC number: 415-650-4 | CAS number: 153965-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data available, ECHA provided study summaries migrated from the SNIF format.
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 415-650-4
- EC Name:
- -
- Cas Number:
- 153965-54-9
- Molecular formula:
- not applicable (multi-constituent)
- IUPAC Name:
- 3-[(2-ethylhexanoyl)oxy]-2,2-bis({[(2-ethylhexanoyl)oxy]methyl})propyl 2-ethylhexanoate; 3-[(2-ethylhexanoyl)oxy]-2,2-bis({[(2-ethylhexanoyl)oxy]methyl})propyl 3,5,5-trimethylhexanoate; 3-[(2-ethylhexanoyl)oxy]-2,2-bis({[(3,5,5-trimethylhexanoyl)oxy]methyl})propyl 3,5,5-trimethylhexanoate; 3-[(2-ethylhexanoyl)oxy]-2-{[(2-ethylhexanoyl)oxy]methyl}-2-{[(3,5,5-trimethylhexanoyl)oxy]methyl}propyl 3,5,5-trimethylhexanoate; 3-[(3,5,5-trimethylhexanoyl)oxy]-2,2-bis({[(3,5,5-trimethylhexanoyl)oxy]methyl})propyl 3,5,5-trimethylhexanoate
- Test material form:
- other: No data available, ECHA provided study summaries migrated from the SNIF format.
- Details on test material:
- No data available, ECHA provided study summaries migrated from the SNIF format.
Constituent 1
Test animals
- Species:
- other: Rat (Sprague-Dawley)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: arachis oil B.P.
- Details on oral exposure:
- Method of administration:
gavage - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 150 mg/kg bw/day
Male: 5 animals at 400 mg/kg bw/day
Male: 5 animals at 1000 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 150 mg/kg bw/day
Female: 5 animals at 400 mg/kg bw/day
Female: 5 animals at 1000 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
Mortality data:
There were no deaths during the study.
Clinical observations:
No clinically observable signs of toxicity were detected in
test or control animals throughout the study period.
Bodyweight:
All test animals showed normal gains in bodyweight
throughout the study period, comparable with control.
Food consumption:
There were no adverse effects on food consumption during the
study. Food efficiency in test animals was comparable with
that seen in controls.
Water consumption:
Visual inspection of water bottles revealed no overt
intergroup differences.
Laboratory findings:
Haematology:
There were no treatment-related changes in the
haematological parameters measured.
Blood chemistry:
There were no blood chemical changes which could be
considered toxicologically significant.
A statistically significant increase (30%) in high dose
female inorganic phosphate was detected in comparison with
controls. The change in isolation was considered to be of no
toxicological significance. Statistically significant
increases in low and high dose female aspartate
aminotrasferase (up to 14%) and intermediate and high dose
female alanine aminotransferase (up to 26%) were detected
but no convincing dose relationship was apparent and all
values were within normally accepted ranges.
Effects in organs:
Necropsy:
High dose animals of both sexes showed slight pallor of the
liver at necropsy. Two females showed a more pronounced
pallor and these individuals, plus two males, also showed
accentuated lobular pattern. High dose males also showed
speckled kidneys, however, this macroscopic abnormality was
not apparent in the females from this dose group.
No treatment-related macroscopic changes were detected in
the other dose groups.
Organ weights:
A slight but statistically significant increase (9%) in
relative kidney weight was detected for high dose males in
comparison with controls. All values were within the
normally expected range for rats of this strain and age,
but, in view of the macroscopic and microscopic changes
identified in these animals, the increase was considered to
be toxicologically significant.
No other significant changes were noted.
Histopathology:
Kidneys; Degeneration and necrosis of renal proximal tubules
were observed for male rats dosed at 150, 400 and
1000mg/kg/day. A similar effect was not observed for female
rats.
No other toxicologically significant changes were observed.
Effect levels
- Remarks on result:
- other: No data available, ECHA provided study summaries migrated from the SNIF format.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Xn - harmful
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