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Diss Factsheets
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EC number: 205-398-1 | CAS number: 140-10-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 27 April 2018 and 18 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Guidance Document EUR 20268 'Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances' (2002).
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of Inspection: 18/07/2017 - 20/07/2017 Date of Issue: 28/11/2017
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- trans-cinnamic acid
- EC Number:
- 205-398-1
- EC Name:
- trans-cinnamic acid
- Cas Number:
- 140-10-3
- Molecular formula:
- C9H8O2
- IUPAC Name:
- 3-phenylacrylic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:
20171106
- Expiration date of the lot/batch:
10 April 2020
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
Room temperature, in the dark, over silica gel
Results and discussion
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- <0.292% of test item has a particle size <10.0 μm therefore it was not possible to determine MMAD or GSD
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 90.2 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- <= 0.292 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- <= 0.116 %
Any other information on results incl. tables
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Measurement |
Result |
Mass of test item transferred to sieve (W1) |
12.26 g |
Mass of test item passed through sieve (W3– W2) |
11.06 g |
Percentage of test item less than 100µm |
90.2% |
Cascade Impactor
The results of the cascade impactor procedure are shown in the following table:
Collection Stage |
Particle Size Range Collected (μm) |
Collected Mass (g) |
||
Determination 1 |
Determination 2 |
Determination 3 |
||
Artificial throat |
n/a |
1.24 |
0,88 |
1.50 |
Sample Cup 1 |
>10.0 |
1.8050 |
2.0459 |
1.5053 |
Sample Cup 2 |
5.5 to 10.0 |
0.0000 |
0.0003 |
0.0053 |
Sample Cup 3 |
2.4 to 5.5 |
0.0000 |
0.0000 |
0.0013 |
Sample Cup 4 |
1.61 to 2.4 |
0.0000 |
0.0000 |
0.0005 |
Sample Cup 5 |
0.307 to 1.61 |
0.0000 |
0.0000 |
0.0005 |
Final Filter |
<0.307 |
0.0000 |
0.0000 |
0.0012 |
Total mass of collected test item |
3.0450 |
2.9262 |
3.0141 |
|
Mass of test item |
3.0418 |
2.9393 |
3.0312 |
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Particle Size Range Collected (μm) |
Collected Mass (g) |
Collective Percentage (%) |
||||
Determination 1 |
Determination 2 |
Determination 3 |
Determination 1 |
Determination 2 |
Determination 3 |
|
<10.0 |
0.0000 |
0.0003 |
0.0088 |
0.00 |
0.01 |
0.292 |
<5.5 |
0.0000 |
0.0000 |
0.0035 |
0.00 |
0.00 |
0.116 |
<2.4 |
0.0000 |
0.0000 |
0.0022 |
0.00 |
0.00 |
0.073 |
<1.61 |
0.0000 |
0.0000 |
0.0017 |
0.00 |
0.00 |
0.056 |
<0.307 |
0.0000 |
0.0000 |
0.0012 |
0.00 |
0.00 |
0.040 |
Mean cumulative percentage with a particle size less than 10.0 μm :≤0.292
Mean cumulative percentage with a particle size less than 5.5 μm :≤0.116
Discussion
Sampling for the cascade impactor determinations was performed by rolling the test item container for approximately 10 minutes and then sampling from the top, middle and bottom.
The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; this gives a worst case scenario.
Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the
alveoli.
Applicant's summary and conclusion
- Conclusions:
- The percentage of test item with an inhalable particle size <100 μm is 90.2%.
The percentage of test item with a thoracic particle size <10.0 μm is ≤0.292%
The percentage of test item with a respirable particle size <5.5 μm is ≤0.116% - Executive summary:
Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268
'Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances' (2002). The results are as follows:
The percentage of test item with an inhalable particle size <100 μm is 90.2%.
The percentage of test item with a thoracic particle size <10.0 μm is ≤0.292%
The percentage of test item with a respirable particle size <5.5 μm is ≤0.116%
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