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Diss Factsheets
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EC number: 230-241-9 | CAS number: 6976-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 48.7 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 487 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 4.87 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 48.7 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 7.28 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 211 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 21.1 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 13.7 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNEC aqua (freshwater)
Acute freshwater aquatic toxicity studies with ETMA were conducted in fish, invertebrates, and algal species. Chronic studies are not available. Fish were the most sensitive trophic level. The PNEC aqua (freshwater) was based on the 96 h LC50 of 48.7 mg/L obtained from the short-term toxicity study in Danio rerio. An assessment factor of 1000 was applied to the LC50 to calculate the PNEC aqua (freshwater) in accordance with Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008.
PNEC aqua (marine)
No tests with marine species are available. The PNEC aqua (marine) was based on the 96 h LC50 of 48.7 mg/L obtained from the short-term toxicity study in Danio rerio. An assessment factor of 10000 was applied to the LC50 to calculate the PNEC aqua (freshwater) in accordance with Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008.
PNEC aqua (intermittent release)
The PNEC aqua (intermittent release) was based on the 96 h LC50 of 48.7 mg/L obtained from the short-term toxicity study in Danio rerio. Based on the available data set, an assessment factor of 100 was applied to the lowest LC50 to calculate the PNEC aqua (intermittent release) in accordance with Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008.
PNEC STP
The PNEC STP was derived using an assessment factor of 10 applied to the EC10 of 72.8 mg/L obtained in an activated sludge respiration inhibition test in accordance with Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008.
PNEC sediment (freshwater, marine)
No toxicity data for sediment dwelling organisms are available. Thus, the PNEC for freshwater as well as marine sediment has been calculated with the equilibrium partitioning method using EUSES 2.1.
The following data have been taken into account for the calculation:
Molecular weight [g/mol] |
144.17 |
Melting point [°C] |
<-100 |
Boiling point [°C] |
175.3 |
Vapour pressure [Pa], 20°C |
22.3 |
Water solubility [mg/L], 20°C |
31330 |
Log Kow |
1.3 |
Koc [L/kg] |
7.41 (MCI method) |
PNEC aqua, freshwater [mg/L] |
0.0487 |
PNEC aqua, marine [mg/L] |
0.00487 |
PNEC soil
No toxicity data for soil organisms are available. Thus, the PNEC for freshwater as well as marine sediment has been calculated with the equilibrium partitioning method using EUSES 2.1.
The following data have been taken into account for the calculation:
Molecular weight [g/mol] |
144.17 |
Melting point [°C] |
<-100 |
Boiling point [°C] |
175.3 |
Vapour pressure [hPa], 20°C |
22.3 |
Water solubility [mg/L], 20°C |
31330 |
Log Kow |
1.3 |
Koc [L/kg] |
7.41 (MCI method) |
PNEC aqua, freshwater [mg/L] |
0.0487 |
PNEC oral
A PNEC oral was not calculated for MTMA since the substance is readily biodegradable. The probability of being rapidly metabolised in exposed organisms is high. Together with the reported log Kow was 1.3 this indicates that there would be only little biomagnification of the test substance in the food chain.
Conclusion on classification
Based on the available reliable and relevant data, short-term toxicity values (L(E)C50) for fish, invertebrates and algae are >1 mg/L. MTMA does not need to be classified for acute toxicity to aquatic organisms according to Regulation EC No 1272/2008 and Directive 67/548/EEC.
No chronic toxicity data are available. However, based on ready biodegradation of MTMA, the criteria for classification for chronic toxicity to aquatic organisms according to Regulation EC No 1272/2008 and Directive 67/548/EEC are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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