Registration Dossier
Registration Dossier
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EC number: 227-217-5 | CAS number: 5718-26-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-1,3,3-trimethylindoline-5-carboxylate
- EC Number:
- 227-217-5
- EC Name:
- Methyl 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-1,3,3-trimethylindoline-5-carboxylate
- Cas Number:
- 5718-26-3
- Molecular formula:
- C25H25N3O3
- IUPAC Name:
- methyl 1,3,3-trimethyl-2-[2-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)ethylidene]indoline-5-carboxylate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Macrolex Orange 51032 (Codenr.: 826-152)
solid powder
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- 3 female; average weight: 3 kg; temperature 19-25 degree Celsius; air humidity 40-60%; 12h/12h light / dark per day.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3 female rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- other: animal 1, 2 and 3
- Time point:
- other: 1, 24, 48, 72 h, 7, 14 and 21 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In an in vivo eye irritation study according to OECD TG 405 no effects (cornea, iris, and conjunctivae) were observed at any time point (1h to 21 days) after exposure to 100 mg in the eyes of 3 rabbits.
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