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Diss Factsheets
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EC number: 221-029-7 | CAS number: 2978-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-01-17 to 2017-05-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- 2015-06-28
- Qualifier:
- according to guideline
- Guideline:
- other: New guidance document on an integrated approach on testing and assessment (IATA) for skin corrosion and irritation, Series on Testing and Assessment No. 203
- Version / remarks:
- 2014-07-11
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1-dimethylprop-3-ynylamine
- EC Number:
- 221-029-7
- EC Name:
- 1,1-dimethylprop-3-ynylamine
- Cas Number:
- 2978-58-7
- Molecular formula:
- C5H9N
- IUPAC Name:
- 2-methylbut-3-yn-2-amine
Constituent 1
- Specific details on test material used for the study:
- - Name (as cited in the study): Golpanol MPA
- Purity: 99.2 area%
- Batch Nr.: 85603856PO
- Batch Nr.:
- Contet: w(C5H9N) = 89.2 g/100 g
- Homogeneity: the test substance was homogeneous by visual inspection
- pH value: ca. 6
- Physical state / color: liquid / colorless, clear
- Storage conditions: room temperature
In vitro test system
- Test system:
- artificial membrane barrier model
- Remarks:
- Corrositex assay
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- The Corrositex® assay was conducted according to the methods described in the Corrositex® Instruction Manual, InVitro International, Irvine CA, USA and Transia GmbH, 35510 Butzbach, Germany 10 April 2016.
- Test kit: Corrositex®, InVitro International, Irvine CA, USA, containing: reagents required for qualification and categorization screen,
biobarrier matrix powder and diluent, membrane discs and vials containing the Chemical Detection System.
- Fume hood: The assay was run in a fume hood - Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
- amount applied: single topical application of 500µL test substance
VEHICLE
- test substance was applied undiluted
NEGATIVE CONTROL
- amount apllied: 500 µL 10% citric acid
POSITIVE CONTROL
- amount applied: one pellet of sodium hydroxide - Duration of treatment / exposure:
- - min. 3 minutes, max. 60 minutes (negative control)
- Number of replicates:
- Four vials were used for the test substance and one vial for the positive control and negative control each.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Duration of treatment / exposure:
- min. 3 minutes, max. 60 minutes (negative control)
- Details on study design:
- ACCEPTANCE CRITERIA
1. breakthrough time for the positive control substance was in the historic control range (mean ± 2-3x standard deviations)
2. negative control was not to induce membrance breakthrough within a 60-minute observation period.
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Value:
- 7.01
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
- Other effects / acceptance of results:
- ACCEPTANCE OF RESULTS:
- Acceptance criteria met for negative control: yes
- Acceptance criteria met for positive control: yes
- Range of historical values if different from the ones specified in the test guideline: breakthrough time of NaOH (solid, historical data) was 12.10 minutes.
Any other information on results incl. tables
Breakthrough times of the test substance, the negative control (NC) and positive control (PC). NB = no breakthrough within maximum observation period (60 minutes).
Test Substance |
Break Through Time [min:s] |
||||
Vial 1 |
Vial 2 |
Vial 3 |
Vial 4 |
Mean |
|
8:48 |
6:49 |
7:01 |
5:26 |
7:01 |
|
Controls: |
|||||
PC: sodium hydroxide, solid |
13:27 |
- |
- |
- |
- |
NC: 10% citric acid |
NB |
- |
- |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
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