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EC number: 232-306-7 | CAS number: 8002-33-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Genetic mutation in vitro;
The read across substances share high similarity in structure and functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for test substance. Experimental data from read across chemical have been reviewed to determine the mutagenic nature of Castor oil, sulfated (8002-33-3).The studies are as mentioned below
The read across substances share high similarity in functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for test substance. Genetic toxicity in vitro study was assessed for test chemical. The test material was exposed to Salmonella typhimurium TA97A and TA102 in the presence and absence of metabolic activation S9. The concentration of test material used in the presence and absence of metabolic activation were0, 0.5-50 mg/plate. No mutagenic effects were observed in both strains, in the presence and absence of metabolic activation. Therefore test chemical was considered to be non mutagenic in Salmonella typhimurium TA97A and TA102 by AMES test. Hence the substance cannot be classified as gene mutant in vitro.
The read across substances share high similarity in functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for target substance. Bacterial reverse mutation assay was performed to evaluate the mutagenic nature of test chemical. The study was performed using Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2 uvrA with and without S9 metabolic activation system up to the limit of solubility. Test chemical failed to induce mutation in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA in the presence and absence of S9 metabolic activation system and hence is not likely to classify as a gene mutant in vitro.
The data available for the target chemical based on its read across substance and applying weight of evidence Castor oil, sulfated (8002-33-3) does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant in vitro.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- WoE derived based on the experimental data from structurally and functionally similar read across chemicals for the target chemical.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Specific details on test material used for the study:
- Name: Castor oil, sulfated
Smiles:CCCCCCC(OS(=O)(=O)[O-])C/C=C\CCCCCCCC(=O)OCC(OC(=O)CCCCCCC/C=C\CC(OS(=O)(=O)[O-])CCCCCC)COC(=O)CCCCCCC/C=C\CC(OS(=O)(=O)[O-])CCCCCC.[Na+].[Na+].[Na+]
InChI:1S/C57H104O18S3.3Na/c1-4-7-10-31-40-51(73-76(61,62)63)43-34-25-19-13-16-22-28-37-46-55(58)70-49-54(72-57(60)48-39-30-24-18-15-21-27-36-45-53(75-78(67,68)69)42-33-12-9-6-3)50-71-56(59)47-38-29-23-17-14-20-26-35-44-52(74-77(64,65)66)41-32-11-8-5-2;;;/h25-27,34-36,51-54H,4-24,28-33,37-50H2,1-3H3,(H,61,62,63)(H,64,65,66)(H,67,68,69);;;/q;3*+1/p-3/b34-25-,35-26-,36-27-;;;
Molecular Weight: 1239.5749 g/mole - Target gene:
- Histidine
- Species / strain / cell type:
- S. typhimurium, other: TA97A and TA102
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- not specified
- Cytokinesis block (if used):
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver, induced with AROCLOR 1254
- Test concentrations with justification for top dose:
- 1,0, 0.5-50 mg/plate
2.Up to limit of soulubility - Vehicle / solvent:
- 1.Distilled water
2,Not specified - Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- not specified
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Details on test system and experimental conditions:
- 1,METHOD OF APPLICATION: Preincubation method
2,Not specified - Rationale for test conditions:
- Not specified
- Evaluation criteria:
- 1.Histidine revertants colonies were observed
2,The plates were observed for a dose dependent increase in the number of revertants - Statistics:
- not specified
- Species / strain:
- S. typhimurium, other: TA97A and TA102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: No mutagenic effct were observed
- Conclusions:
- Gene mutation toxicity study for Castor oil, sulfated (8002-33-3) as predicted using data from read across chemicals for Salmonella typhimurium bacterial strains in the presence and absence of S9 metabolic activation system is negative and hence the chemical is not likely to classify as a gene mutant in vitro.
- Executive summary:
Genetic mutation in vitro;
The read across substances share high similarity in structure and functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for test substance. Experimental data from read across chemical have been reviewed to determine the mutagenic nature of Castor oil, sulfated (8002-33-3).The studies are as mentioned below
The read across substances share high similarity in functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for test substance. Genetic toxicity in vitro study was assessed for test chemical. The test material was exposed to Salmonella typhimurium TA97A and TA102 in the presence and absence of metabolic activation S9. The concentration of test material used in the presence and absence of metabolic activation were0, 0.5-50 mg/plate. No mutagenic effects were observed in both strains, in the presence and absence of metabolic activation. Therefore test chemical was considered to be non mutagenic in Salmonella typhimurium TA97A and TA102 by AMES test. Hence the substance cannot be classified as gene mutant in vitro.
The read across substances share high similarity in functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for target substance. Bacterial reverse mutation assay was performed to evaluate the mutagenic nature of test chemical. The study was performed using Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2 uvrA with and without S9 metabolic activation system up to the limit of solubility. Test chemical failed to induce mutation in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA in the presence and absence of S9 metabolic activation system and hence is not likely to classify as a gene mutant in vitro.
The data available for the target chemical based on its read across substance and applying weight of evidence Castor oil, sulfated (8002-33-3) does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant in vitro.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Genetic mutation in vitro;
The read across substances share high similarity in structure and functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for test substance. Experimental data from read across chemical have been reviewed to determine the mutagenic nature of Castor oil, sulfated (8002-33-3).The studies are as mentioned below
The read across substances share high similarity in functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for test substance. Genetic toxicity in vitro study was assessed for test chemical. The test material was exposed to Salmonella typhimurium TA97A and TA102 in the presence and absence of metabolic activation S9. The concentration of test material used in the presence and absence of metabolic activation were0, 0.5-50 mg/plate. No mutagenic effects were observed in both strains, in the presence and absence of metabolic activation. Therefore test chemical was considered to be non mutagenic in Salmonella typhimurium TA97A and TA102 by AMES test. Hence the substance cannot be classified as gene mutant in vitro.
The read across substances share high similarity in functional group .Therefore, it is acceptable to derive information on mutation from the analogue substance for target substance. Bacterial reverse mutation assay was performed to evaluate the mutagenic nature of test chemical. The study was performed using Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2 uvrA with and without S9 metabolic activation system up to the limit of solubility. Test chemical failed to induce mutation in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA in the presence and absence of S9 metabolic activation system and hence is not likely to classify as a gene mutant in vitro.
The data available for the target chemical based on its read across substance and applying weight of evidence Castor oil, sulfated (8002-33-3) does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant in vitro.
Justification for classification or non-classification
Thus based on the above annotation and CLP criteria for target substance Castor oil, sulfated (8002-33-3)does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant in vitro.
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