Registration Dossier
Registration Dossier
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EC number: 200-158-2 | CAS number: 52-90-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vivo
Description of key information
At concentrations of 10, 50 and 100 μg / mL, L-cysteine caused a slight increase of the exchange between brothers' chromosomes (SCE) in human lymphocytes.
The three doses have shown the same high frequency of SCE, which was considered one metabolic response instead of genotoxic. No SCE has been observed in cells V79 of Chinese hamster incubated with L-cysteine. Negative results even in tests of chromosomal aberration on Chinese hamster ovary cells, incubated with Lcisteina at concentrations up to 5000 μg / mL.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Bibliographic source:
Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from Commission on Flavouring Group Evaluation 79, (FGE.79) Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) The EFSA Journal (2008) 870, 1-46.
Justification for classification or non-classification
No classification is proposed based on available data
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