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EC number: 223-804-5 | CAS number: 4079-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-diethyl-2-propynylamine
- EC Number:
- 223-804-5
- EC Name:
- N,N-diethyl-2-propynylamine
- Cas Number:
- 4079-68-9
- Molecular formula:
- C7H13N
- IUPAC Name:
- diethyl(prop-2-yn-1-yl)amine
Constituent 1
- Specific details on test material used for the study:
- - Name as used in study report: Golpanol DEP; Diethylaminopropin
- Physical: clear yellowish liquid
- Purity: 99%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Mura: SPRA (SPF 68 Han), Firma MUS RATTUS, Brunnthal,
- Body weight range: 185 ± 15 g
- The animals were offered Herilan MRH of H. EGGERSMANN KG, Rinteln/Weser, and tap water ad libitum during the post-exposure observation period.
- The animals were kept in fully air-conditioned rooms (temperature 22 ± 2°C and humidity 55 ± 5%) with a day/night rhythm of 12 hours.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- - A concentration estimated on the basis of the data from the inhalation hazard test was used as a first orienting concentration. A concentration allows a no effect level to be established (0 lethality).
- Dynamic inhalation system. Whole-body inhalation system (groups of 5 animals are placed in wire cages which are located in a glass-steel inhalation chamber, V = 200 L)
- Generator system: Continuous infusion pump UNITA I; glass evaporator with thermostat
- By means of a continuous infusion pump, constant amounts of the test substance were supplied to an evaporator heated to 49°C. The vapors that were formed were mixed with a flow of fresh air and passed into the inhalation chamber.
- By means of an exhaust air system, the pressure ratios in the inhalation system were adjusted in such a way that there was a pressure slightly below the atmospheric pressure (negative pressure) . - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- - Analytical concentrations: 0.60, 1.54, 1.86, 2.64, 5.95 mg/L
- Nominal concentrations: 1.60, 4.02, 5.35, 8.03, 9.64 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - After the exposure period, the surviving animals were observed for 14 days.
- The body weight of the animals was checked before the beginning of the test, after 7 days and at the end of the observation period. The absolute body
weight gain and the relative body weight gain (difference in weight between the initial weight of the animals and the following weights) were determined from the values and presented graphically.
- Clinical findings and lethality were recorded daily.
- At the end of the 14-day observation period, the animals were sacrificed with C02 and were subjected to a gross-pathological examination like all other animals which had died before. - Statistics:
- The statistical evaluation of the experiment was based on a probit analysis by D.J. Finney (D. J. Finney; Probitanalysis 1971, page 1 - 150, publisher: Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London N.W. 1.)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2.1 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- - 0.6 (1.6) mg/L and 1.54 (4.02) mg/L: no deaths;
- 1.86 (5.35) mg/L: 5/10 male and 5/10 females dead animals
- 2.64 (8.03) mg/L: 7/10 male and 8/10 females dead animals
- 9.64 (5.95) mg/L: 10/10 male and 10/10 female dead animals - Clinical signs:
- other: - All dose groups: watery eye/nasal secretion (partly reddish), eyelid closure, salivation, intermittent breathing, crouching position, abdominal position, twitching, trembling rsp. clonic convulsions, apathy, staggering gait, ruffled fur. - All symptoms
- Body weight:
- - Males showed no abnormalities in the body weight growth (compared with the control group).
- Female animals of the test group 2 (2.64 resp. 8.03 mg/L) showed a reduced body weight gain. - Gross pathology:
- Animals that died:
- Heart: acute dilatation of the atrium;
- Acute congestive hyperemia;
- Lung: intense blood filling with slight edema;
- Liver: broadened, loam-brown liver lobe periphery; partly liver with lateral corrugation.
Sacrificed animals:
- Nothing abnormal detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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