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EC number: 813-543-0 | CAS number: 73984-93-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct 1981
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The skin preparation was not exactly performed in accordance to OECD Guideline 404.
- Principles of method if other than guideline:
- Detailed description of guideline deviations:
- Skin preparation: At 24 hours prior to study initiation, the fur on the back of each rabbit was clipped from an area approximately 240 cm2, and the skin was examined for abnormalities. On the day of treatment, four test sites (2.5 cm x 2.5 cm each), two on either side of the midline, were designated in the clipped area on the back of each rabbit. The test sites on the right side were abraded in a pattern with a hypodermic needle so as to penetrate the stratum corneum but not the dermis. The test sites on the left side were left intact. The results from the adraded test sites have been excluded from the calculation of the primary irritation index as the use of abraded skin does not follow current OECD test guidelines.
- Expsoure: Also the application was for 24 h rather than the current OECD guideline exposure time of 4 h. Therefore, this represents a worst case. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-
- EC Number:
- 813-543-0
- Cas Number:
- 73984-93-7
- Molecular formula:
- C14H26N2S4
- IUPAC Name:
- 1,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Lesser's Rabbitry, Union Grove, WI
- Weight at study initiation: 2.5 to 3.1 kg
- Fasting period before study: No
- Housing: Individually housed in stainless steel cages (61.0 x 45.5 x 42.0 cm)
- Diet: Rabbits were fed Purina Rabbit Chow Complete Blend (Ralston Purina Co.) ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 22
- Humidity (%): approx. 40 (relative)
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES:
1981-10-13 - 1981-10-27
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL applied to each test site
- Concentration: neat material used - Duration of treatment / exposure:
- A 0.5 mL quantity of the test article was applied to each of the four test sites and covered with a 2.5 x 2.5 cm gauze pad which was secured by an adhesive dressing (CoverletR, Beiersdorf Inc., S. Norwalk. Conn.). The mid-section of the rabbit was wrapped in a lint-free cloth towel to prevent removal of the gauze pad while allowing the rabbit free movement. All wrapping materials and gauze pads were removed 24 hours after application and the test sites were washed with a 0.9 % sodium chloride solution to remove any residual test article.
- Observation period:
- The test sites were examined and scored 1, 3, 7 and 14 days after application for oedema, erythema, and eschar formation. Each test site was scored for irritation according to the method of Draize.
- Number of animals:
- 6 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 4 test sites 2.5 x 2.5 cm on the back of each rabbit
- Type of wrap if used: gauze pad secured by an adhesive dressing (CoverletR, Beiersdorf Inc., S. Norwalk. Conn.). The mid-section of the rabbit was wrapped in a lint-free cloth towel to prevent removal of the gauze pad while allowing the rabbit free movement.
REMOVAL OF TEST SUBSTANCE
- Washing: 0.9 % sodium chloride solution
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.86
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.65
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritant / corrosive response data available.
- Other effects:
- No other effects reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant)
- Remarks:
- Migrated information Does not require classification. Criteria used for interpretation of results: EU
- Conclusions:
- The test report describes a valid guideline study. No information about GLP compliance is available. The test material is not considered to be a primary dermal irritant.
- Executive summary:
A dermal irritation study was conducted using a similar procedure to that described in the current OECD Guideline 404 (Reckers, 1982). The test material (CAS No. 73984 -93 -7) was applied at a dose of 0.5 mL to the backs of 6 female rabbits (strain: New Zealand White). The test article was left in contact with the skin for 24 hours and then the test sites were washed with 0.9% sodium chloride and the rabbits observed during this time and for 14 days after its removal. The test sites were scored at 1, 3, 7 and 14 days after removal. Oedema and erythema were observed in all rabbits 3 days following application and in the majority of rabbits 7 days following test article application. Mean erythema scores of 0.66 (1-day observation), 2 (3-day observation) and 1.33 (7-day observation) were reported. In addition, mean edema scores of 1.33 (3-day and 7-day observation, respectively) were determined. All effects were fully reversible within 14 days. Besides, all test animals appeared normal 14 days after application. No rabbits died during the study.
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