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EC number: 271-928-3 | CAS number: 68630-95-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
This substance is an amphoteric surfactant and has uses in the Cosmetics industry. Under the cosmetics regulation, animal testing is not allowed on substances used in such products. There is no available in-vivo acute oral toxicity data for this substance and none can be generated.
Data has been found relating to similar UVCB substances in published review documents for alkyl imidazolines and imidazoline derivatives
suggest that these substances are of low oral toxicity and pose little concern for human health. One set of data suggest that the level may be just below the 2000 mg/kg/bw limit for no classification, where the other set of data suggest that the level is >5000 mg/kg/bw.Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Specific details on test material used for the study:
- Alkyl imidazoline is a UVCB material contininag structures which are very similar to the substance under test.
There are no studies for this substance and due to a ban on animal testing for such end points, it is necessry to try to find an alternative way of making an assessment using other substances that have been tested in-vivo in previous years. - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 213 - <= 2 546 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 259 - <= 2 638 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 1 515 - <= 2 349 mg/kg bw
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Alkyl imidazoline is a UVCB material contininag structures which are very similar to the substance under test.
There are no studies for this substance and due to a ban on animal testing for such end points, it is necessry to try to find an alternative way of making an assessment using other substances that have been tested in-vivo in previous years. - Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Specific details on test material used for the study:
- The amphoteric surfactants in this group include structures designated as alkylamphoacetates, alkylamphopropionates, and alkyliminopropionates. These surfactants are usually produced by the reaction of fatty acids or their esters with amines (e.g. aminoethylethanol amine). Alkylamphopropionates may be obtained by the addition of acrylic acid, methyl acrylate, or ethyl acrylate to the reaction product of fatty acids and amines. During the synthesis of most of the surfactants an intermediate imidazoline ring structure may be formed (hence the common name ‘imidazoline derivatives’). The imidazoline ring is probably opened by the influence of hydrolysing conditions and does not appear in the final products (Domsch 1995).
- Species:
- rat
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In-vivo acute oral toxicicty data that are available for these imidazoline derivatives suggest that these substances are of low oral toxicity and pose no concerns for human health.
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study waived due to provisions of other regulation
- Justification for data waiving:
- other:
Referenceopen allclose all
Alkyl imidazoline, 1-(2-Hydroxyethyl)-2-alkyl*-2-imidazoline (*as in fatty acids of tall oil), has been tested in the following acute toxicity
tests. With Sprague-Dawley rats (MRID No. 42293001), alkyl imidazoline demonstrated an acute oral LD of 1948 (1259-2638) mg/kg body weight 50 for male rats, 1880 (1213-2546) mg/kg for female rats, and 1932 (1515 - 2349) mg/kg for combined sexes.
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.