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Diss Factsheets
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EC number: 214-154-3 | CAS number: 1100-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 7th, 2017 to December 4th, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- Medium was prepared before the Study Plan was officially signed by the Study Director. This has no impact on the validity or integrity of the study.
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Analytical purity: >=99.5%
- Purity test date: 02 March 2017
- Lot/batch No.: 180739
- Expiration date of the lot/batch: Not specified
- Appearance: Off-white powder
- Storage: At room temperature - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: secondary effluent from a municipal sewage treatment plan receiving predominantly domestic sewage
- Details on inoculum:
- - Source: Waterschap Aa en Maas, 's-Hertogenbosch, The Netherlands
- Treatment: filtered through a coarse filter paper (irst 200 mL discarded) and kept aerated until inoculation.
- Inoculation: 4 mL filtrate of secondary effluent per litre of final volume - Duration of test (contact time):
- 28 d
- Initial conc.:
- 1 mg/L
- Based on:
- test mat.
- Remarks:
- no correction was made for the purity/composition of the test item
- Initial conc.:
- 3 mg/L
- Based on:
- test mat.
- Remarks:
- no correction was made for the purity/composition of the test item
- Parameter followed for biodegradation estimation:
- O2 consumption
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: test item
- Remarks:
- 1 mg/L
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
- Remarks on result:
- other: test item
- Remarks:
- 3 mg/L
- Results with reference substance:
- In the procedure control, sodium acetate was degraded by at least 60% (72%) within 14 days (79% and 72% on day 7 and 14 respectively).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item was not readily biodegradable under the conditions of the closed bottle test performed.
- Executive summary:
The aerobic biodegradability of the test item was investigated in a GLP-compliant ready biodegradability study performed in accordance with OECD Guideline No. 301 D. The relative biodegradation values calculated from the O2 measurements performed during the test period of 28 days revealed no biologically relevant biodegradation of the test item. The reference item was degraded >50% in the toxicity control (no inhibitory effects). The test item was not readily biodegradable under the conditions of the closed bottle test performed.
Reference
Theoretical Oxygen Demand
The ThOD of benzyltriphenylphosphonium chloride (test item) was calculated to be 2.59 mg O2 per mg.
The ThOD of sodium acetate (reference item) was calculated to be 0.78 mg O2/mg.
Biodegradation
The relative biodegradation values calculated from the O2 measurements performed during the test period of 28 days revealed no biologically relevant biodegradation of benzyltriphenylphosphonium chloride at both concentrations. In the toxicity control less than 25% biodegradation occurred within 14 days (29% and 21% on day 7 and 14 respectively, based on ThOD). However, in the toxicity control the contribution of the ThOD of the reference and test item differs significantly (1.56 mg O2/L for the reference item versus 2.59 mg O2/L for the test item). Therefore, evaluation of the toxicity control based on ThOD is not the most appropriate method, as the ThOD is overestimated due to the higher ThOD of the test item. Results on day 14 showed that in the toxicity control an oxygen depletion of 0.84 mg O2/L was observed, compared to 1.12 mg O2/L for the reference item, while there was no oxygen depletion observed for the test item. This means the reference item was degraded >50% in the toxicity control and that sufficient microbial activity was present for biodegradation, i.e. no inhibitory effects.
Test Conditions
The pH at the start of the test was 7.4 in all vessels. The temperature recorded in a vessel with water in the same room varied between 22 and 23°C.
Acceptability of the Test
1. Oxygen depletion in the inoculum blank was less than 1.5 mg O2/L after 28 days (0.27 mg O2/L).
2. The residual concentration of oxygen in the test bottles was > 0.5 mg/L at any time.
3. All differences of duplicate biodegradation values expressed as mg O2/L were less than 20% (1-10%).
4. In the procedure control, sodium acetate was degraded by at least 60% (72%) within 14 days (79% and 72% on day 7 and 14 respectively).
Since all criteria for acceptability of the test were met, this study was considered to be valid.
Description of key information
The aerobic biodegradability of the test item was investigated in a GLP-compliant ready biodegradability study performed in accordance with OECD Guideline No. 301 D. The relative biodegradation values calculated from the O2 measurements performed during the test period of 28 days revealed no biologically relevant biodegradation of the test item. The reference item was degraded >50% in the toxicity control (no inhibitory effects). The test item was not readily biodegradable under the conditions of the closed bottle test performed.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
The aerobic biodegradability of the test item was investigated in a GLP-compliant ready biodegradability study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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