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EC number: 203-715-8 | CAS number: 109-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Magnesium methanolate hydrolyses rapedly in contact with moisture or water into methanol and magnesium hydroxide (detailed description in section 5.1.2). Both hydrolysis products are not dangerous for aquatic organisms and no classification is required.
Hydrolysis product methanol:
Methanol is the first and simplest member of the series of aliphatic alcohols. Like other non-reactive, non-ionizable organic chemicals ("neutral organics") such as ketones, ethers, alkyl halides, aryl halides and aromatic hydrocarbons methanol is expected to exert toxicity to aquatic species through simple narcosis.
A large amount of data on the toxicity of methanol is available for a broad spectrum of aquatic organisms (fish, invertebrates and algae).
The results from the most reliable and relevant available studies are listed below
Short-term toxicity
Fish
LC50 (96h) = 28100 mg/L Pimephales promelas
LC50 (96h) = 20100 mg/L Oncorhynchus mykiss
LC50 (96h) = 15400 mg/L Lepomis macrochirus
Daphnids
EC50 (48h) = 18000 mg/L Daphnia magna
EC50 (48h) > 10000 mg/L Daphnia magna
Green algae
EC50 (96h) ca. 22000 mg/L Selenastrum capricornutum
Microorganisms
EC 50: 19800 mg/L activated sludge
IC50: >1000 mg/L activated sludge
IC50: 880 mg/L Nitrosamonas
toxic limit concentration: 530 - 6600 mg/L Pseudomonas, Microcystis aeruginosa.
All the available data demonstrate consistently the very low acute toxicity to methanol for aquatic organisms
Long-term toxicity
No fully reliable results and no guideline studies are available concerning long-term toxicity of methanol to aquatic species. Given the Biological Oxygen Demand of methanol and its rapid biodegradation, it is indeed difficult to maintain in long-term tests the required levels of oxygen concentration. Due to this aspect, it also difficult to assess the reliability of studies, in which the oxygen concentration is not well documented.
Since methanol belongs to the category of chemicals acting with a non-specific mode of action (simple narcosis) the chronic toxicity to aquatic organism can be reasonably predicted from data on acute toxicity using an appropriate acute-to-chronic ratio. An ACR of 10 has been proposed in the literature for such kind of chemicals(see for example Raimondo et al., Environ. Toxicol. Chem. 26, 2007; Roex at al., Environ. Toxicol. Chem. Cryo Letters. 2004 Nov-Dec; 25(6):415-2419, 2000).
Taking into account the toxicity mode of action of methanol the chronic toxicity to aquatic organisms can be also reasonably predicted using Structure-Activity Relationship models (QSARs).
The available information and the results from toxicity estimations indicate a very low chronic toxicity of methanol to aquatic organisms, with no-effect levels well above the concentrations which are normally used in limit tests on long-tern toxicity.
Fish
NOEC (predicted chronic value): 447 mg/l Pimephales promelas
NOEC (200h) = 7900 - 15800 mg/L Oryzias latipes
Daphnids
NOEC (21 d) = 208 mg/L (predicted) Daphnia magna
NOEC (21 d) = 122 mg/L Daphnia magna
Hydrolysis product magnesium hydroxide:
Magnesium hydroxide has no short-term toxicity to fish. The two key studies for this endpoint concluded that the LC50s for freshwater fish were 306.79 mg/L and 775.8 mg/L, respectively. The supporting studies found that magnesium hydroxide has a very low toxicity to all fish tested.
Long-term toxicity of fish is unlikely to occur based on the physico-chemical properties of magnesium hydroxide, the breakdown pathway of the substance and the fact that magnesium ions are ubiquitous in the natural environment.
Magnesium hydroxide is of low acute toxicity to aquatic organisms and does not meet the criteria to be classified as dangerous under the CLP Regulation (EC) No 1272/2008 nor does it meet the criteria to be classified as persistent, bioaccumulative or toxic under the REACH Regulation.
Reported results on the physico-chemical properties of Magnesium hydroxide show that the substance is only slightly soluble in water (1.78 mg total solids/L at 8.3 pH and 20ºC) and has a low potential to adsorb to sediment (derived sediment-water partition coefficient (Kd) 1.65). Furthermore, Magnesium hydroxide is expected to break down in the environment to water and magnesium over time. Magnesium is ubiquitous in the environment and is an essential plant and animal nutrient.Magnesium sulphate and magnesium chloride, and hence the magnesium ion, all have a very low toxicity to aquatic invertebrates.The recalculated LC50 (96h) for D. Magna was determined as 170.86 mg/L with 100% pure Magnesium hydroxide. Supporting studies on magnesium chloride all shows low long-term toxicity to aquatic invertebrates
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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