Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 946-992-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4th May 2017 to 1st June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The test material is a UVCB
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- An inoculum containing an active microbial population was prepared as follows. Six days prior to test initiation, a sample of secondary effluent was collected from the Guelph Wastewater Treatment Plant (Guelph, Ontario). The secondary effluent was continuously aerated during transport to, and storage at AquaTox, and then pre-conditioned for testing. During preconditioning, the secondary effluent was maintained at test temperature (22 ± 2 °C) prior to test initiation. The secondary effluent was settled for 40 minutes prior to the clear supernatant being decanted for use as the inoculum.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 2.23 mg/L
- Based on:
- test mat.
- Initial conc.:
- 4 mg/L
- Based on:
- COD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The test involved exposure of an active microbial population (secondary effluent from a wastewater treatment plant) to the test item for 28 days under constant temperature in the dark. Initial oxygen demand for the test item was determined from the Chemical Oxygen Demand (COD) The test item was evaluated at approximately 4.0 mg COD test item/L in a series of test chambers. During the test, the bacteria utilize a nutrient solution (devoid of carbon) and the test item (the carbon source), consuming dissolved oxygen in the process. The dissolved oxygen from each biodegradation test vessel was measured with an oxygen electrode on a frequency adequate to track the degradation of the test item (i.e., on Days 0, 4, 7, 14, 21 and 28). The test was terminated on the 28th day.
The amount of oxygen consumed within the test system was compared to the COD of the test substance and the percent (%) degradation was calculated. The 28-day biodegradation curve for the test item was prepared using calculations prescribed in the test method and by graphical representation. The degradation rates of the test item and degradation values for any point in time were calculated and reported to the nearest 0.1%.
Since the test item did not contain nitrogen, there was no requirement to collect samples for analysis of nitrate and nitrite. - Reference substance:
- other: Potassium Hydrogen Phthalate (KHP)
- Remarks:
- KHP, which does not degrade in the absence of an inoculum within the duration of the test, was selected over the reference substances recommended by OECD (1992) which will degrade in water in the absence of an inoculum
- Test performance:
- The reference substance achieved >60% degradation within 14 days of test initiation.
• The difference of extremes of replicate values of the removal of the test item at the plateau, at the end of the test or at the end of the 10- day window, as appropriate, was less than 20%.
• Inoculated control (nutrient blank) did not exhibit more than 1.5 mg/L reduction in dissolved oxygen concentration.
• The residual dissolved oxygen concentration in the test vessels did not fall below 0.5 mg/L.
• The toxicity control achieved > 25% degradation in 14 days - Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 6.2
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Details on results:
- Reference Series (Procedural Control)
Percent Biodegradation of the Reference Substance After 14 and 28 Days
Duration (Days) Percent Degradation
14 85.0
28 91.2
Inhibition Series (Toxicity Control)
Percent Biodegradation in the Inhibition Test After 14 and 28 Days
Duration (Days) Percent Degradation
14 41.9
28 45.0
Test Item Series (Test Suspension)
Estimate of the Ready Biodegradability of the Test Item After 28 Days
Test Item Degradation (%) after 28 days
X-19933 6.2
Comment;
* The percentage degradation is the average of two replicates. The accuracy of the dissolved oxygen meter is +/-2%
* Since the test item did not contain nitrogen, there was no requirement to collect samples for analysis of nitrate and nitrite. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The pecentage degradation obtained by the test item in the first 28 days was 6.2%. Therefore, the test item is not considered to be readily biodegradable according to OECD Guideline 301D (i.e., did not achieve 60% degradation within the 28-day test period).
- Executive summary:
The study was conducted in accordance with the OECD 301 D Biodegradability Closed Bottle Test guideline to investigate the ready biodegradability of the test item. The test exposes microorganisms to the test items, which they utilise as carbon source. The test involved exposure of an active microbial population (secondary effluent from a
wastewater treatment plant) to the test item for 28 days under constant temperature in the dark. Initial oxygen demand for the test item was determined from the Chemical Oxygen Demand (COD). The test item was evaluated at approximately 4.0 mg COD test item/L in a series of test chambers. During the test, the bacteria utilize a nutrient solution (devoid of carbon) and the test item (the carbon source), consuming dissolved oxygen in the process. The dissolved oxygen from each biodegradation test vessel was measured with an oxygen electrode on a frequency adequate to track the degradation of the test item (i.e., on Days 0, 4, 7, 14, 21 and 28). The test was terminated on the 28th day. The amount of oxygen consumed within the test system was compared to the COD of the test substance and the percent (%) degradation was calculated. The 28-day biodegradation curve for the test item was prepared using calculations prescribed in the test method and by graphical representation. The degradation rates of the test item and degradation values for any point in time were calculated and reported to the nearest 0.1%.
The percentage degradation obtained by the test item in the first 28 days was 6.2%. Therefore, the test item is considered to be non rapidly biodegradable according to the CLP crietria for classification and labelling.
Reference
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.