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EC number: 230-089-3 | CAS number: 6940-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Both acute oral and dermal toxicities were examined. 1 -Bromo-4 -chlorobutane has slight toxicity for oral and low toxicity for dermal.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Specific details on test material used for the study:
- Purity 99.6%
Lot No. 917 - Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sprague-Dawley
- Females (if applicable) nulliparous and non-pregnant: [yes/no] no information
- Age at study initiation: five weeks old
- Weight at study initiation: 106 - 139 g for female, 100 - 132 g for male
- Fasting period before study: 18 hours
- Housing: 54 x 33 x 20 cm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period:at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 °C (18 - 25 °C)
- Humidity (%): 55 % (40 - 70 %)
- Air changes (per hr): 15 complete air changes per hours without re-circulation.
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: To: from one to fifteen - Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 ml/kg - Doses:
- Preliminary study :400 mg/kg, 800 mg/kg, 2000 mg/kg
Main study : 800 mg/kg, 1265 mg/kg, 2000 mg/kg, 3162 mg/kg - No. of animals per sex per dose:
- Preliminary study: one male and one female rat per dose group
Main study: five male and five female rats per dose group - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Frequency of observation: The first hour after dosing and two further inspection during the remainder of Day 1. From Day 2 onwards, inspected twice a day.
The body weight Recorded on the day before dosing and on Days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:none - Statistics:
- Probit analysis by the method of Finney (1971) was used to determine the acute median lethal dosage, 95% confidence interval and slope of the dose response curve of the test material for both sexes, The calculations were performed by the GLIM statistics program (Baker and Nelder, 1978) using a special macro program developed by Baker (Baker, 1980)
- Preliminary study:
- Dosage (mg/kg) Mortality
Male Female
400 0/1 0/1
800 0/1 0/1
2000 1/1 0/1 - Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 591 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 160 - <= 2 021
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 167 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 354 - <= 2 981
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Remarks:
- combined
- Effect level:
- 1 885 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 542 - <= 2 228
- Mortality:
- Animals died at dosages of 1265 mg/kg or above. The deaths occurred during the first over-night period and on the second and fourth days after dosing
- Clinical signs:
- Ante mortem signs comprised lethargy, decreased motor activity, prone position, staggering gait, muscle tremor, bradypnoea, tachypnoea, hyperpnoea, hypopnoea, cold to touch, pigmented staining of the snout, piloerection, ungroomed apprearance, thin body conformation, salivation, hunched posture, closed eyes, pigmented and serous orbital secretion and reddening.
Sign of reaction to treatment in the surviving animals comprised irritability, lethargy, staggering gait, decreased motor activity, cold to the touch, piroerection, salivation, hunched posture, eyes, serous orbital discharge and reddening The animas were overtly normal six days after treatment. - Body weight:
- The surviving animals achieved expected body weight gains.
- Gross pathology:
- Necropsy of the decendents revealed low incidences or single cases of abnormal stomack contents, dark areas on the stomach glandular mucosa, pale cranial fur staining, hairloss on cervical dorsum, pale areas on the liver, large liver and pale kidneys.
Necropsy of the surviving animals revealed pale areas on the liver with interlobular adhesions, abnormal gastro-intestinal contents, dark sub-mandibular and mandibular lymph nodes and testicular masses amongst two males and distended uterus in two females - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this study the acute oral median lethal dosage (LD50) were 1591 mg/kg for male, 2167 mg/kg for female and 1885 mg/kg as combined. Accordingly, TMCB was assigned to the class 'slight oral toxicity.
- Executive summary:
Under the conditions of this study the acute oral median lethal dosage (LD50) were 1591 mg/kg for male, 2167 mg/kg for female and 1885 mg/kg as combined. Accordingly, TMCB was assigned to the class 'slight oral toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1 885 mg/m³
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992 - 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- Lot No. 0917
- Species:
- rat
- Strain:
- other: CD strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: remote Sprague-Dawley origin
- Females (if applicable) nulliparous and non-pregnant: not applicable
- Age at study initiation: male: seven to eight weeks old, female: ten to eleven weeks old
- Weight at study initiation: male: 226 - 254 g, female: 223 - 247 g
- Fasting period before study: not applicable
- Housing:54 x 33 x 20 cm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 C, (range: 18 - 25C)
- Humidity (%): 55% R.H. (range 40% - 70% R.H.)
- Air changes (per hr): 15 times per hour
- Photoperiod (hrs dark / hrs light): 12 hours dark/ 12 hours light - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5 cm x 5cm
- % coverage: 10 % of the body surface
- Type of wrap if used: the test material was applied to a gauze patch, placed on the dorsum and occulated with aluminium foil.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wipe with wet disposal towels
- Time after start of exposure:24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Concentration (if solution): neat
- Constant volume or concentration used: no
- For solids, paste formed: no
VEHICLE
- Amount(s) applied (volume or weight with unit):not specified
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- five male and five female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:The first hour after administration and two further inspections during the remainder of Day 1. From Day 2 onwards, the animals were inspected twice daily. Each dermal application site was examined at the morning observation.
The body weight was recorded on the day before dosing and on Days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:none - Statistics:
- Not applicable
- Preliminary study:
- A preliminary study was carried out using a group of one male and one female given TMCB at a dosage of 1000 mg/kg bodyweight. There was no death.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal died during the day after dosing.
- Clinical signs:
- Ante mortem signs comprised underactivity, staggering gait, hunched poisture and bulging eyes.
Signs of reaction to treatment in the surviving animals comprised underactivity, staggering gait, ungroomed appearance, pigmented staining of the snout, hunched posture, thin body conformation and bulging eyes. The female wer overtly normal by Day 3, while the males had recovered by Day 8.
There were no local signs of reaction to treatment at the dermal application site. - Body weight:
- Reduced bodyweight gain or slight bodyweight loss was recorded during the first week of observation for the majority of surviving animals. Increments during the second week were generally satisfactory.
- Gross pathology:
- Necropsy of the decedent and the surviving animals, revealed no significant macroscopic lesion.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the acute percutaneous median lethal dosage (LD50) of the test material was greater than 2000 mg/kg. Accordingly, 1-bromo-4-chlorobutane, TMCB, was assigned into the class ' low percutaneous toxicity',
- Executive summary:
Under the conditions of this study, the acute percutaneous median lethal dosage (LD50) of the test material was greater than 2000 mg/kg. Accordingly, 1-bromo-4-chlorobutane, TMCB, was assigned into the class ' low percutaneous toxicity',
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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