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EC number: 245-082-0 | CAS number: 22564-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: hydrolysis determination due to results from pre-test
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The test item Toluzonchlorid had to be tested for its water solubility. During the preliminary test it was found that after 24 hours in water the test showed a not negligible decomposition. Hence the water solubility can't be determined.
In a second measurement the hydrolysis was observed over 14 hours. The concentrations of the test item and the hydrolysis compound were screened. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: pre-test; hydrolysis
Test material
- Reference substance name:
- N-(2-chloroethyl)-N-ethylaniline
- EC Number:
- 245-082-0
- EC Name:
- N-(2-chloroethyl)-N-ethylaniline
- Cas Number:
- 22564-43-8
- Molecular formula:
- C11H16ClN
- IUPAC Name:
- N-(2-chloroethyl)-N-ethylaniline
Constituent 1
Results and discussion
Water solubility
- Key result
- Remarks on result:
- not determinable
- Details on results:
- The water solubility of Toluzonchlorid could not be determined due to the fast hydrolysis. The hydrolysis product was identified as N-Ethyl-N-2-hydroxyethyl-m-toluidine.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of Toluzonchlorid could not be determined due to the fast hydrolysis. The test item showed a degradation of approx. 50 % in the first 60 minutes. This behaviour occurred also in the next 1 h steps. The hydrolysis product was identified as N-Ethyl-N-2-hydroxyethyl-m-toluidine.
- Executive summary:
The test item Toluzonchlorid has been tested for its water solubility in a GLP study (2017).
During the preliminary test it was found that after 24 hours in water the test showed a not negligible decomposition. Hence the water solubility can't be determined.
Therefore the results of the preliminary test are reported:
For the calibration function the test item was solved in acetonitrile. In the HPLC-UV chromatogram there is only one peak assigned to the test item.
After stirring for 24 hours in water the test solution was investigated with HPLC-UV. It was found that the test item showed only small area-percent but there was a second, much bigger peak assigned to a decomposition product.
The pH-value of the test solution was measured. It is determined as between 4 and 5 at the beginning and the end of the stirring time.
The decomposition product was identified with a reference compound.
In a second measurement the hydrolysis was observed over 14 hours. The concentrations of the test item and the hydrolysis compound were screened.
Result: The water solubility of Toluzonchlorid could not be determined due to the fast hydrolysis. The test item showed a degradation of approx. 50 % in the first 60 minutes. This behaviour occurred also in the next 1 h steps. The hydrolysis product was identified as N-Ethyl-N-2-hydroxyethyl-m-toluidine.
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