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EC number: 619-573-9 | CAS number: 855425-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- July 28, 2009 to January 12, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- - OECD Guideline for Testing of Chemicals, Guideline No. 117: ”Partition coefficient (n-octanollwater), High Performance Liquid Chromatography (HPLC) ’ method”, adopted April 13, 2004 - EEC directive 92/69, Annex V, Part A, Methods for the determination of physico-chemicai properties, A.8 ”Partition coefficient”, 1992
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- and EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- CAT-Nitrile
- IUPAC Name:
- CAT-Nitrile
- Details on test material:
- Name: CAT-NITRIL
Certificate of Analysis Date: June 27,2008
Aggregate State at Room Temperature: Liquid
Colour: Colourless - light brown
Expiry Date: September 2009
Stability: Technical product: see expiry date
Storage: In original container, at room temperature (+10 degree C to +30 degree C), in the
dark
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.6 - 5.1
- Temp.:
- 25 °C
- Remarks on result:
- other: The logarithmic partition coefficients (n-octanol/water) of the test item were determined to be 3.6 and 5.1 using the HPLC method (25 degree C +/- 1 degree C).
Any other information on results incl. tables
The partition coefficient of the test item was determined from its
retention time on a reversed phase column in comparison with
recommended reference items. Although the test item is considered
to be stable two test item related peaks occur in the chromatogram
of the test item. A second signal might be based on possible reaction
products of the test item (e.g. hydrolysis). Two partition coefficients
for the test item were calculated.
Applicant's summary and conclusion
- Conclusions:
- The logarithmic partition coefficients (n-octanol/water) of the test
item were determined to be 3.6 and 5.1 using the HPLC method
(25 degree C +/- 1 degree C). - Executive summary:
Title:
Determination of the Partition Coefficient (n-Octanol / Water) of
CAT-NITRIL, by High Performance Liquid Chromatography (HPLC)
Guidelines/Recommendations:
-OECD Guideline for Testing of Chemicals, Guideline No.117:
”Partition coefficient (n-octanol/water), High Performance
Liquid Chromatography (HPLC) method”, adopted April 13,
2004
- EEC directive 92/69, Annex V, PartA, Methods for the
determination of physico-chemical properties, A.8 ”Partition
coefficient”,1992
Purpose:
The purpose of the study was to determine the partition coeficient
of the test item between n-octanol and water using the HPLC method.
Results:
.
The partition coefficient was calculated based on a calibration curve
usingGreference items. The difference between the three
measurements of the reference mixture was less than the given 0.1
log units. Therefore, the study is considered to be valid.
The partition coefficient of the test item was determined from its
retention time on a reversed phase column in comparison with
recommended reference items. Two test item related peaks occur in
the chromatogram of the test item, therefore two partition
coefficients for the test item were determined.
The logarithmic partition coefficients (n-octanol/water) of the test
item were determined to be 3.6 and 5.1 using the HPLC method
(25 degree C +/- 1 degree C).
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