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EC number: 630-459-8 | CAS number: 1225197-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 29 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC/ECHA
- Overall assessment factor (AF):
- 18
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 529 mg/m³
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC concept (combined inter-/intraspecies differences)
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 176 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC/ECHA
- Overall assessment factor (AF):
- 3
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 529 mg/m³
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC concept (combined inter-/intraspecies differences)
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: ECETOC/ECHA
- Overall assessment factor (AF):
- 72
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC concept (combined inter-/intraspecies differences)
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Most sensitive endpoint:
- skin irritation/corrosion
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.3 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- DNEL derivation method:
- other: Refer to discussion
- Overall assessment factor (AF):
- 3
- Dose descriptor:
- other: NOAEL
- AF for intraspecies differences:
- 3
- Justification:
- Refer to discussion
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.3 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- DNEL derivation method:
- other: Refer to discussion
- Overall assessment factor (AF):
- 3
- Dose descriptor starting point:
- other: NOAEL
- AF for intraspecies differences:
- 3
- Justification:
- Refer to discussion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
Workers:
Acute / Short-term – systemic effects
Dermal DNEL
No threshold effect: Substance is corrosive and sensitising. Effects following dermal exposures will be characterized by local corrosive and possible sensitizing effects that are related to duration, quantity and concentration of the substance, rather than by systemic toxicity due to dermal uptake. Specifically as acute oral toxicity is low.
For corrosive substances, the use of protective gloves and other equipment, such as face shields, aprons and good work practices are mandatory. As a result, direct dermal contact occurs only occasionally. Therefore, repeated substantial daily dermal exposure is unlikely. (For properly labelled corrosives, the emphasis in the CSR and ES should be on the presentation of adequate risk management measures, rather than on the assessment of the risks from dermal exposure.)
Inhalation DNEL
Substance is corrosive and sensitizing.The likelihood for exposure via inhalation and thus experience respiratory irritation or becoming sensitised to AAI, is very lowconsidering the high boiling point (> 300 °C) and very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI). In case of high exposure by inhalation, local effects will be more prominent then possible systemic effects considering the low systemic toxicity seen in acute oral toxicity testing
However, some calculations can be made for systemic effects following short-term inhalation exposure by extrapolating information from anOECD 422 study on Tall oil reaction products with tetraethylene-pentamine (Amidoamine/Imidazoline) showing a NOAEL of 300 mg/kg/day. This would certainly be protective for levels of acute inhalation expected to lead to similar systemic exposure levels.
The corrected 8 hr inhalation NOAEC for workers is NOAEL (300 mg/kg) * 1.76 mg/m3 = 529 mg/m3 (assuming no difference in absorption following oral and inhalation exposure). Assessment factors further applied: No interspecies factor is needed due to allometric scaling applied in calculation of corrected NOAEC. Further combined inter-/intraspecies for workers AF = 3 (ECETOC concept). As this involves acute exposures, no extrapolation for duration is needed.
This results in a DNEL of 529/3 = 176 mg/m3.A short term/acute exposure at this level can be assumed not to lead to systemic toxicity.
Acute / Short term – local effects
Dermal DNEL
Substance is corrosive and sensitizing. For corrosive substances, the use of protective gloves and other equipment, such as face shields, aprons and good work practices are mandatory. As a result, direct dermal contact occurs only occasionally. Therefore, repeated substantial daily dermal exposure is unlikely. (For properly labelled corrosives, the emphasis in the CSR and ES should be on the presentation of adequate risk management measures, rather than on the assessment of the risks from dermal exposure.)
An indication for possible threshold effects for irritation comes from an available sensitisation study on Fatty acids C16-18, C18 unsat reaction products with tetraethylenepentamine. In a GPMT 1% in an aqueous solution (0.9% NaCl) was found to be non-irritant (0.5 mL, 24 hrs, occlusive on rabbit skin).
This level could be used for indication of DNEL for local irritating effects. No interspecies AF is required. An AF of 3 is proposed to cover for intra-species variation for workers, leading to a DNEL for short-term local dermal effects of about 0.3%.
Inhalation DNEL
Substance is corrosive and sensitizing.The likelihood for exposure via inhalation, and thus experience respiratory irritation or becoming sensitised to AAI, is very lowconsidering the high boiling point (> 300 °C) and very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI). Furthermore, as the substance is classified as corrosive, no acute toxicity testing should normally be conducted. As there are no data on local effects,no inhalation DNEL can be established for local effects.
Long-term exposure – systemic effects
Dermal DNEL
Substance is corrosive and sensitising. Effects following dermal exposures will be characterized by local corrosive effects that are related to duration, quantity and concentration of the substance, rather than by systemic toxicity due to dermal uptake. However, a DNEL can be derived by route-to-route extrapolation from an oral NOAEL.An OECD 422 combined 28-day/reproduction screening study resulted to an overall NOAEL of 300 mg/kg/day being the highest dose level tested.
Derived dermal NOAEL would be 300 mg/kgbw/d (assuming same dermal and oral absorption as worst case) and the following assessment factors: AF = 4 for allometric scaling (default). Combined inter-/intra-species for workers AF = 3 (ECETOC concept). Exposure duration from sub-acute to chronic AF = 6.
This results in a total assessment factor of 4 x 3 x 6 = 72, indicating that the DNEL will be 300/72 = 4.2 mg/kg bw/day.
Inhalation DNEL(aerosol)
An OECD 422 combined 28-day/reproduction screening study resulted to an overall NOAEL of 300 mg/kg/day being the highest dose level tested.
For aerosol inhalation absorption the following is suggested: Assumed is that the major part of the inhaled substance will be deposited in the upper respiratory tract, which will finally be taken up orally. No difference in absorption is considered between inhalation and oral ingestion.
The corrected 8 hr inhalation NOAEC for workers is NOAEL(300 mg/kg) * 1.76 mg/m3 = 529 mg/m3.
Further assessment factors applied: No interspecies factor is needed due to allometric scaling applied in calculation of corrected NOAEC. Combined inter-/intra-species for workers AF = 3 (ECETOC concept). Exposure duration from sub-acute to chronic AF = 6.
This results in a total assessment factor of 3 x 6 = 18, indicating that the DNEL will be 529/18 = 29 mg/m3.
Long-term exposure – local effects
Dermal DNEL
Substance is corrosive and sensitizing. For corrosive substances, the use of protective gloves and other equipment, such as face shields, aprons and good work practices are mandatory. As a result, direct dermal contact occurs only occasionally. Therefore, repeated substantial daily dermal exposure is unlikely. (For properly labelled corrosives, the emphasis in the CSR and ES should be on the presentation of adequate risk management measures, rather than on the assessment of the risks from dermal exposure.).
Considered is that protection of irritation for short-term exposures, is also protective for irritation following repeated exposures. An indication for possible threshold effects for irritation comes from an available sensitisation study on Fatty acids C16-18, C18 unsat reaction products with tetraethylenepentamine. In a GPMT 1% in an aqueous solution (0.9% NaCl) was found to be non-irritant (0.5 mL, 24 hrs, occlusive on rabbit skin). This level could be used for indication of DNEL for local irritating effects. No interspecies AF is required. An AF of 3 is proposed to cover for intra-species variation for workers, leading to a DNEL for local dermal irritation of about 0.3%.
Inhalation DNEL
Substance is corrosive and sensitizing.The likelihood for exposure via inhalation and thus experience respiratory irritation or becoming sensitised to AAI, is very lowconsidering the high boiling point (> 300 °C) and very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI). Furthermore, as the substance is classified as corrosive, no acute toxicity testing should normally be conducted. As there are no data on local effects,no inhalation DNEL can be established for local effects.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.7 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC/ECHA
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 261 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Refer tp discussion
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC - Combined inter-/intraspecies for consumers/general population
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC/ECHA
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Refer to discussion
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default
- AF for intraspecies differences:
- 5
- Justification:
- Combined inter-/intraspecies for consumers/general population
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC/ECHA
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default
- AF for intraspecies differences:
- 5
- Justification:
- Combined inter-/intraspecies for consumers/general population
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Additional information - General Population
These substances are only applied in professional or industrial setting in oilfield and mining applications applying adequate PPE. Use results to the inclusion into or onto a matrix. Consequently, consumers/general population will not be exposed.
However, in order to be able to evaluatepossible secondary exposures via environment, additionally long-term systemic DNELs for general population have been derived.
Long-term exposure – systemic effects
Dermal DNEL
Substance is corrosive and sensitising. Effects following dermal exposures will be characterized by local corrosive effects that are related to duration, quantity and concentration of the substance, rather than by systemic toxicity due to dermal uptake. However, a DNEL can be derived by route-to-route extrapolation from an oral NOAEL. An OECD 422 combined 28-day/reproduction screening study resulted to an overall NOAEL of 300 mg/kg/day being the highest dose level tested.
Derived dermal NOAEL would be 300 mg/kgbw/d (assuming same dermal and oral absorption as worst case for dermal exposures). The following assessment factors are used for the oral and dermal DNEL:
- AF = 4 for allometric scaling (default).
- Combined inter-/intra-species for consumers/general population: AF = 5 (ECETOC concept).
- Exposure duration from sub-acute to chronic AF = 6.
This results in a total assessment factor of 4 x 5 x 6 = 120. This leads to a consumer/general public long-term DNEL for systemic effects via dermal or oral exposures of 300/120 = 2.5 mg/kg bw/day.
Inhalation DNEL(aerosol)
An OECD 422 combined 28-day/reproduction screening study resulted to an overall NOAEL of 300 mg/kg/day being the highest dose level tested.
For aerosol inhalation absorption the following is suggested: Assumed is that the major part of the inhaled substance will be deposited in the upper respiratory tract, which will finally be taken up orally. No difference in absorption is considered between inhalation and oral ingestion.
The corrected 8 hr inhalation NOAEC for general population is NOAEL(300 mg/kg) * 1/1.15 mg/m3 = 261 mg/m3.
Further assessment factors applied:
- No interspecies factor is needed due to allometric scaling applied in calculation of corrected NOAEC.
- Combined inter-/intra-species for consumers/general population: AF = 5 (ECETOC concept).
- Exposure duration from sub-acute to chronic AF = 6.
This results in a total assessment factor of 5 x 6 = 30, indicating that the DNEL will be 261/30 = 8.7 mg/m3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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