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EC number: 272-723-1 | CAS number: 68909-93-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Stability in organic solvents and identity of relevant degradation products
Administrative data
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: No guideline available. The study was performed according to a substance specific method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The stability of the test substance in n-octanol is determined by comparing GC chromatograms of a freshly prepared solution of the substance to a solution of the substance in n-octanol stored for a period of 24 hours at 22 deg. C. The storage conditions reproduce the conditions under which the substance was in contact with the solvent during OECD 107 partition coefficient testing.
Chromatograms are obtained following derivatization of the substance according to procedure described in the publication: "Structural determination of zinc dithiophosphates in lubricating oils by gas chromatography-mass spectrometry with electron impact and electron-capture negative ion chemical ionization" in Journal of Chromatography A. 905 (2001) 207-222.
Chromatograms are compared both qualitatively (by retention times of eluted peaks) and quantitatively on the basis of peak areas to determine any significant loss of components.
Results of a GC analysis are used as the basis for determining the suitability of the shake flask method in determining the partition coefficient of the substance. A deviation of > 10% in the concentration of the substance or a significant change in the GC chromagograms between t = 0 and t =24 hours is used as the criterion for evaluating stability. - GLP compliance:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts
- EC Number:
- 272-723-1
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts
- Cas Number:
- 68909-93-3
- Molecular formula:
- Too complex
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts
- Details on test material:
- -Substance type: a coordination compound consisting of a zinc metal complex bonded to dialkyldithiophosphate ligands
Constituent 1
Results and discussion
- Test substance stable:
- yes
- Transformation products:
- no
Any other information on results incl. tables
The tables below shows < 10% change in the concentration of the test substance and in the GC peak area percents of individual component after a 24 hour storage in n-octanol at 22 deg. C
Table 1. Stability of Test Substance in n-Octanol (24 hours at 22 C)
Time (hours) |
Sum GC Peak Areas |
mg/L |
0 |
23072 |
793 |
24 |
21096 |
732 |
% difference in concentration after 24 hours |
-7.7 % |
GC Peak Area % of Components in Substance After Storage in n-Octanol (24 hours at 22 C)
GC Peak |
1 |
2 |
3 |
4 |
5 |
6 |
Peak Retention time (min) |
8.16 |
10.68 |
10.84 |
13.44 |
13.55 |
13.65 |
0 hours |
22.11% |
29.87% |
33.37% |
3.21% |
7.92% |
3.53% |
24 hours |
22.88% |
29.35% |
31.89% |
3.52% |
8.62% |
3.74% |
GC chromatorams are attached as Figure 1
Applicant's summary and conclusion
- Conclusions:
- GC-MS analyses indicate the substance is stable in n-octanol when in contact with this organic solvent for a period of 24 hours at 22 deg. C and the shake flask method is suitable for the determination of the partition coefficient of this substance.
- Executive summary:
The stability of the test substance in n-octanol is determined by comparing a freshly prepared solution of the substance to a solution of the substance in n-octanol stored for a period of 24 hours at 22 deg. C. The storage conditions reproduce the conditions under which the substance was in contact with the solvent during OECD 107 partition coefficient testing.
The compositions of the substance at t = 0 and t = 24 hours were compared by GC -MS following derivatization to halogenated derivatives with pentafluorobenzyl bromide (CASRN 1765-40-8). The derivatization process produces pentafluorobenzyl-phosphorodithioic acid molecules more amenable to GC separation than the starting zinc dialkyldithiophosphate complex.
Chromatograms were compared both qualitatively (by retention times of eluted peaks) and quantitatively on the basis of peak areas (which are proportional to the amount of a component) to determine any significant losses due to contact with n-octanol.
Results of the analysis indicate the substance is stable in n-octanol for the duration of the OECD 107 partition coefficient study by the shake flask method. The criterion for stability was < 10% change in concentration of the substance or differences in the peak area per cents of the individual components.
The stability of the substance was not evaluated in other solvents as it is not stored in other organic solvents prior to testing for other physico-chemical properties.
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