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EC number: 230-811-7 | CAS number: 7328-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD 404 and conducted according to GLP of the US EPA, CFR Part 792
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- small deviations
- Principles of method if other than guideline:
- no step-wise approach used, 6 animals used
exposed skin area 10 cm2 instead of 6 cm2 - GLP compliance:
- yes
Test material
- Reference substance name:
- SR 256, HXF 0946; no further ID of test substance
- IUPAC Name:
- SR 256, HXF 0946; no further ID of test substance
- Test material form:
- other: liquid
- Details on test material:
- - Clear liquid
- Used as received
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Six healthy New Zeland Albino rabbits ( 3 males and 3 females ) 2.0 -2,.4 kg bw were individually caged with a light/dark cycle of 12 hours under temperture controlled conditions.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of the test article was applied.
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 14 days;
Observation points: > 1hrs , 24 hrs, 48 hrs, 72 hrs, 7 d, 14d - Number of animals:
- 6: 3 males and 3 females
- Details on study design:
- similar to OECD 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 30 min to 1 hrs
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- 0.83
- Max. score:
- 1
- Remarks on result:
- other: 1/6 brown areas on the skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 hrs
- Score:
- 1.67
- Max. score:
- 2
- Remarks on result:
- other: 1/6 brown areas on the skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hrs
- Score:
- 1.67
- Max. score:
- 2
- Remarks on result:
- other: 1/6 brown areas on the skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 2.5
- Max. score:
- 4
- Remarks on result:
- other: 5/6 flaking skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: day 14
- Score:
- 0.5
- Max. score:
- 1
- Remarks on result:
- other: 1/6 poor hair regrowth, 2/6 flaking skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 30 min to 1 hr
- Score:
- 3.33
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- 2.83
- Max. score:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 hrs
- Score:
- 2.17
- Max. score:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hrs
- Score:
- 1.83
- Max. score:
- 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 7 d
- Score:
- 1.66
- Max. score:
- 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 14 d
- Score:
- 0.5
- Max. score:
- 1
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
Under the conclusion of this study, the test article is an irritant but not corrosive and thus fulfill the CLP-classification criteria as Skin Irrit 2, H315.- Executive summary:
Six healthy New Zeland Albino rabbits ( 3 males and 3 females ) were dosed dermally with SR 256 HXF 0946. 0.5 ml of test article was applied under semi-occlusive conditions on intact clipped skin. The test article was kept in contact with the skin for 4 hours. Draize scoring was performed after ½-1, 24, 48, 72 hours and 7 and 14 days. The scoring indicated the substance to be a moderate to severe irriatant but not a corrosive as irreversible damage and necrosis was not observed.
According to the CLP-criteria the substance should be classified as Skin Irrit 2, H315.
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