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EC number: 233-343-1 | CAS number: 10124-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Supporting study:
Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate.
Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
Link to relevant study records
- Endpoint:
- three-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate. Two litters per generation were examined.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Route of administration:
- oral: feed
- Details on exposure:
- Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate or 0.05% Sodium
Trimetaphosphate. Two litters per generation were examined. - Details on mating procedure:
- The rats (16 females and 8males per group) were mated when the rats were each 100 days old.
- Conclusions:
- Diet containing 0.05% Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
- Executive summary:
Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate.
Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
Reference
Diet containing 0.05% Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
Effects on developmental toxicity
Description of key information
Supporting study:
Wistar rats were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant rats a given up to 240 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed.
The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
Supporting study:
CD-1 mice e were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant a given up to 370 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- Pregnant Wistar rats were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Route of administration:
- oral: gavage
- Conclusions:
- For pregnant rats a given up to 240 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
- Executive summary:
Wistar rats were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant rats a given up to 240 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed.
The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- Pregnant CD-1 mice were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Route of administration:
- oral: gavage
- Conclusions:
- For pregnant mice a given up to 370 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
- Executive summary:
CD-1 mice e were treated via oral intubation with up to 1600 mg/kg Sodium Hexametaphosphate on days 6 to 15 of gestation. For pregnant a given up to 370 mg/kg/day respectively, no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
Referenceopen allclose all
For pregnant rats given up to 240 mg/kg/day no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
For pregnant mice given up to 370 mg/kg/day no effects on nidation, maternal survival, or fetal survival were observed. The incidence of skeletal or visceral abnormalities of the fetuses did not differ from that of controls.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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