Registration Dossier
Registration Dossier
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EC number: 277-179-9 | CAS number: 72987-16-7
Endpoint summary
Administrative data
Description of key information
The acute toxicity (oral) for Reactive Blue 181 was assessed in a weight-of-evidence approach containing three studies (rat, oral, gavage). The following LD50 values were determined:
- LD50 (male, female) > 5000 mg/kg bw
- LD50 (male) > 5000 mg/kg bw
- LD50 (male) > 5000 mg/kg bw; LD50 (female) = 4170 mg/kg bw
It can be concluded that Reactive Blue 181 is not acutely toxic via oral exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Weight-of-evidence approach with three studies performed with test items of different purity. No adverse effects observed.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The LD50s determined in three acute oral toxicity studies (rat, gavage) were >2000 mg/kg bw which is the cut-off value for classification.
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