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EC number: 223-954-1 | CAS number: 4133-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) is predicted by using OECD QSAR tool box v. 3.4 using log Kow as primary descriptor. The test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one undergoes 18.11 % degradation by considering BOD as parameter and Microorganisms as inoculum in 28 days. Based on percent biodegradability it is concluded that test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS No. 4133 -34 -0). If released in to the environment, 22.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.172 %), indicates that test chemical7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS No. 4133 -34 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 77.0 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in soil is estimated to be 75.0 days (1800 hrs). Based on this half-life value of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
Additional information
Biodegradation in water:
Predicted data for target compound 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) and supporting weight of evidence studies for its closest read across chemicals with log Kow as a primary descriptor were reviewed for the biodegradation endpoint which are summarized as below.
In first weight of evidence study the Biodegradability of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) was predicted by using OECD QSAR tool box v. 3.4 using log Kow as primary descriptor. The test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one undergoes 18.11 % degradation by considering BOD as parameter and Microorganisms as inoculums in 28 days. Based on percent biodegradability it is concluded that test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not readily biodegradable.
Another prediction was done by using the Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is expected to be not readily biodegradable.
The supporting weight of evidence study done from authoritative database ( J check, 2017) in this study the Biodegradation experiment was carried out of read across chemical 1-Chloro-2,5-dimethoxybenzene (CAS no. 2100-42-7) by taking activated sludge as inoculums at 30 mg/L concentration . The initial concentration of read across chemical taken was 100 mg/L. Biodegradation was analyzed by using two parameters namely BOD and HPLC. The study design was of standard type. Percent biodegradation of read across chemical 1-Chloro-2,5-dimethoxybenzene was observed to be 0.0 % by both BOD and HPLC parameters in 28 days. Therefore it is concluded that read across chemical 1-Chloro-2,5-dimethoxybenzene is not readily biodegradable.
Similarly, another supporting weight of evidence study done from same source as mentioned above ( J check, 2017)in this study the Biodegradation experiment was carried out of read across chemical 1-chloro-2-[(1-chloropropan-2-yl)oxy]propane (CAS no.108-60-1) by taking activated sludge as inoculums at 30 mg/L concentration. The initial concentration of read across chemical taken was 100 mg/L. Biodegradation was analyzed by using three parameters namely BOD, TOC and GC. The study design was of improved type for volatile substance. Percent biodegradation of read across chemical 1-chloro-2-[(1-chloropropan-2-yl)oxy]propane was observed to be 0.0 % by BOD and GC parameters and 6.0 % by TOC parameter in 28 days. Therefore it is concluded that read across chemical 1-chloro-2-[(1-chloropropan-2-yl)oxy]propane is not readily biodegradable.
On the basis of above results for target chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) from EPI suite 2017 and OECD QSAR tool box v3.4, 2017 and for its read across substances (from authoritative database) the target chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one can be expected to be not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one(CAS No. 4133 -34 -0). If released in to the environment, 22.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.172 %), indicates that test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS No. 4133 -34 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 77.0 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-onein soil is estimated to be 75.0 days (1800 hrs). Based on this half-life value of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
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