Registration Dossier
Registration Dossier
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EC number: 250-205-6 | CAS number: 30449-81-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Test on the basis of H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. .23, 95 - 107 (1962)
- GLP compliance:
- no
- Test type:
- other: BASF method
- Limit test:
- no
Test material
- Reference substance name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- EC Number:
- 250-205-6
- EC Name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- Cas Number:
- 30449-81-1
- Molecular formula:
- C23H29N5O3
- IUPAC Name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Inhalation by means of vapour saturated at 20°C for 8 hours. To achieve saturation, air (200 L/h) was fed through an approx. 5 cm deep layer of the product.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- saturation concentration
- No. of animals per sex per dose:
- 12
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observation, weekly weighing
- Necropsy of survivors performed: yes - Statistics:
- N/A
Results and discussion
- Preliminary study:
- NA
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: no effect on saturation concentration
- Mortality:
- no deaths
- Clinical signs:
- other: no effects
- Body weight:
- no data
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this acute inhalation study, 8 hours inhalation of the volatile constituents of the test material did not lead to any deaths in rats (0/12).
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