Registration Dossier
Registration Dossier
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EC number: 207-997-3 | CAS number: 504-63-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Insufficient methodology to evaluate results.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 941
- Report date:
- 1941
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Propane-1,3-diol
- EC Number:
- 207-997-3
- EC Name:
- Propane-1,3-diol
- Cas Number:
- 504-63-2
- Molecular formula:
- C3H8O2
- IUPAC Name:
- propane-1,3-diol
- Details on test material:
- Name of test material (as cited in study report): Trimethylene glycol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- not specified
- Doses:
- 3, 5, 6, 7, 7.5, 8, and 9 cc/kg
- No. of animals per sex per dose:
- at least 4/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 - 7 other: cc/kg
Any other information on results incl. tables
Results are as follows: 1. 100% mortality (n=9) at 8 and 9 cc/kg 2. 75% mortality (of n=8) at 7.5 cc/kg 3. 80% mortality (of n=5) at 7 cc/kg 4. 40% mortality (of n=5) at 6 cc/kg 5. 0% mortality (of n=15) at either 3 or 5 cc/kg
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
