Registration Dossier
Registration Dossier
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EC number: 204-671-2 | CAS number: 124-02-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Diallylamine [124-02-7]: Review of Toxicological Literature
- Author:
- US National Toxicology Program
- Year:
- 1 997
- Bibliographic source:
- US National Toxicology Program
- Reference Type:
- secondary source
- Title:
- Workplace Exposure Limit Documentation – Diallylamine
- Author:
- Hoechst Celanese Corporation
- Year:
- 1 996
- Bibliographic source:
- -
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 1, 4 and 8 hour exposure to rats (exposure concentrations different between exposure durations).
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Diallylamine
- EC Number:
- 204-671-2
- EC Name:
- Diallylamine
- Cas Number:
- 124-02-7
- Molecular formula:
- C6H11N
- IUPAC Name:
- diallylamine
Constituent 1
- Specific details on test material used for the study:
- Purity not provided.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 1 - <= 8 h
- Concentrations:
- 4 hour exposure: 1500 - 5070 ppm (5960.7 - 20147.3 mg/m3 = 5.96 mg/L - 20.15 mg/L).
1 hour exposure: 7000 ppm (27816.8 mg/m3 = 27.8 mg/L)
8 hour exposure: 450 - 1500 ppm (1788.2 mg/m3 - 5960.7 mg/L = 0.45 - 5.96 mg/L)
Specific dose groups not specified. - No. of animals per sex per dose:
- 5 per group (for all exposure durations)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: not specified
- Necropsy of survivors performed: not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 10.95 other: mg/L
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: LC50 in ppm = 2755
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 27.8 other: mg/L
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: LC50 in ppm = >7000
- Remarks:
- The 1 hr LC50 converted into 4 hr LC50 estimate is 13.9 mg/L
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 3.16 other: mg/L
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: LC50 in ppm = 795
- Remarks:
- The 8 hr LC50 conveted into 4 hr LC50 estimate is 4.47 mg/L
- Mortality:
- 1 hour exposure: No mortality.
4 hour exposure: Mortalites but data not specified.
8 hour exposure: Mortalites but data not specified.
Any other information on results incl. tables
The 1 hour LC50 result of 27.8 mg/L was converted into a 4 hour LC50 result of 13.9 mg/L by dividing the 1 hour result by a factor of 2 (applicalbe for gases and vapours).
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- A 4-hour rat LC50 of 10.95 mg/L (2755 ppm) is reported.
- Executive summary:
The actue inhalation toxicity of diallylamine was examined by exposure (vapour) to rats for 1, 4 and 8 hours.
Rats were exposed to diallylamine (vapour) for 1, 4 and 8 hours. The tested concentrations were:
1 hour exposure: 7000 ppm (27.8 mg/L)
4 hour exposure: 1500 - 5070 ppm (5.96 mg/L - 20.15 mg/L).
8 hour exposure: 450 - 1500 ppm (0.45 - 5.96 mg/L)
The following results are reported:
A 4-hour rat LC50 of 10.95 mg/L is reported.
No mortalities were observed after the 1 hour exposure and a 1 hour LC50 of 27.8 mg/L is reported. This converts to a 4 hour LC50 estimate of 13.9 mg/L.
A 8-hour LC50 of 3.16 mg/L is reported. This converts to a 4 hour LC50 estimate of 4.47 mg/L
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