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EC number: 206-033-9 | CAS number: 294-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 09/1964
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Method: other: Farbenfabriken Bayer AG; details described in sections "Test animals" and "Administration/Exposure"
- GLP compliance:
- no
- Test type:
- other: description of inhalative tests see under "Administration/Exposure"
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclododecane
- EC Number:
- 206-033-9
- EC Name:
- Cyclododecane
- Cas Number:
- 294-62-2
- Molecular formula:
- C12H24
- IUPAC Name:
- cyclododecane
- Details on test material:
- IUCLID4 Test substance: "pure" cyclododecane, no further information
Constituent 1
Test animals
- Species:
- other: 20 mice, 10 rats, 2 guinea pigs, 1 rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: Test 1: methylene chlorid : alcohol (1:1); Test 2: no vehicle; Test 3: no vehicle
- Details on inhalation exposure:
- TEST 1:
In a 2 m3 exposure chamber, 20 ml of a 10 % solution of cyclododecane in methylene chloride/alcohol (1:1) was sprayed at intervals of 1/2 hour in the presence of the test animals. The mean concentration was 1.49 mg/l (indirect determination with "oil Red"). Duration of the test was 4 hours.
TEST 2:
In a 400 l exposure chamber, 10 g of pure cyclododecane were heated constantly at 100 degree C in the presence of the test animals, which caused sublimation of all 10 g of the test substance in the course of the exposure period (4 hours).
TEST 3:
In a 400 l exposure chamber, on each of 5 consecutive days 4 g of pure cyclododecane were sublimed by heating at 100 degree C in the presence of the test animals. The post exposure observation period was 14 days. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- only done for Test 2: mean concentration: 1.49 mg/l (indirect determination with "oil red")
- Duration of exposure:
- 4 h
- Remarks on duration:
- 4 hours in Test 1+2; 4 hours/day on 5 consecutive days in Test 3
- Concentrations:
- see in section "Details on inhalation exposure"
- No. of animals per sex per dose:
- 1 rabbit, 2 guinea pigs, 10 rats, 20 mice per test
- Control animals:
- no
- Details on study design:
- see in section "Details on inhalation exposure"
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
- Mortality:
- No mortalities described in tests 1, 2 and 3.
- Clinical signs:
- other: TEST 1: The animals showed some restlessness and irritation of the mucosa during exposure but recovered soon afterwards. TEST 2: The animals showed minor impairment of general condition but recovered soon after the end of exposure. TEST 3: No symptoms
- Body weight:
- not reported
- Gross pathology:
- no data
- Other findings:
- no other findings
Any other information on results incl. tables
RS-Freetext:
TEST 1: The animals showed some restlessness and irritation of the mucosa during exposure but recovered soon afterwards.
TEST 2: The animals showed minor impairment of general condition but recovered soon after the end of exposure.
TEST 3: No symptoms of intoxication could be observed.
Applicant's summary and conclusion
- Conclusions:
- After inhalation of cyclododecane for 4 hours (Test 1 and Test2) the examined animals (1 rabbit, 2 guinea pigs, 10 rats, 20 mice) showed only transient mild clinical signs (e.g. restlessness, irritation of mucosa) which recovered soon after end of exposure. No symptoms of intoxication could be observed in Test 3, where the animals were exposed to cyclododecane via inhalation for 5 consecutive days (4 hours/day). No mortalities were described for tests 1, 2 and 3.
- Executive summary:
TEST 1:
In a 2 m3 exposure chamber, 20 ml of a 10 % solution of cyclododecane in methylene chloride/alcohol (1:1) was sprayed at intervals of 1/2 hour in the presence of the test animals (1 rabbit, 2 guinea pigs, 10 rats, 20 mice).
The mean concentration was 1.49 mg/l (indirect determination with "oil Red"). Duration of the test was 4 hours. The animals showed some restlessness and irritation of the mucosa during exposure but recovered soon afterwards.
TEST 2:
In a 400 l exposure chamber, 10 g of pure cyclododecane were heated constantly at 100 degree C in the presence of the test animals (animals: see test 1), which caused sublimation of all 10 g of the test substance in the course of the exposure period (4hours). The animals showed minor impairment of general condition but recovered soon after the end of exposure.
TEST 3:
In a 400 l exposure chamber, on each of 5 consecutive days 4 g of pure cyclododecane were sublimed by heating at 100 degree C in the presence of the test animals (animals: see test 1). The post exposure observation period was 14 days.
No symptoms of intoxication could be observed.
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