Registration Dossier
Registration Dossier
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EC number: 202-219-9 | CAS number: 93-11-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of the given test chemical on rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium naphthalene-2-sulphonate
- EC Number:
- 208-523-8
- EC Name:
- Sodium naphthalene-2-sulphonate
- Cas Number:
- 532-02-5
- IUPAC Name:
- sodium naphthalene-2-sulfonate
- Details on test material:
- - Name of test material (IUPAC name): Sodium naphthalene-2-sulphonate
- Common name: Sodium 2-naphthalenesulfonate
- Molecular formula: C10H7NaO3S
- Molecular weight: 230.2183 g/mol
- Smiles notation: c1ccc2cc(ccc2c1)S(=O)(=O)[O-].[Na+]
- InChl: 1S/C10H8O3S.Na/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10;/h1-7H,(H,11,12,13);/q;+1/p-1
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Sodium 2-naphthalenesulfonate
- Molecular formula :C10H7NaO3S
- Molecular weight :230.2183 g/mol
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 13900 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 13 900 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% Mortality was observed at dose 13900 mg/kg bw.
- Mortality:
- 50% Mortality was observed at dose 13900 mg/kg bw.
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 13900 mg/kg bw, when rats were treated with the given test chemical orally.
- Executive summary:
Acute oral toxicity study was conducted by using the given test chemical in rats at the dose concentration of 13900 mg/kg bw via oral route. Animals were observed for mortality. 50% Mortality was observed at dose 13900 mg/kg bw. Hence, the lethal concentration (LD50) value for acute oral toxicity test was considered to be 13900 mg/kg bw, when rats were treated with the given test chemical orally.
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