Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-351-6 | CAS number: 35081-45-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4'-benzyloxy-2-bromopropiophenone
- EC Number:
- 252-351-6
- EC Name:
- 4'-benzyloxy-2-bromopropiophenone
- Cas Number:
- 35081-45-9
- Molecular formula:
- C16H15BrO2
- IUPAC Name:
- 1-[4-(benzyloxy)phenyl]-2-bromopropan-1-one
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- 30% DMSO / 70% PEG 400 used as vehicle control.
- Frequency of treatment:
- Single administration.
- Post exposure period:
- 24 h and 48 h after a single administration of the test item the bone marrow cells were collected for micronuclei analysis.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 500 mg/kg bw/day
- Remarks:
- 24 h preparation interval
- Dose / conc.:
- 1 000 mg/kg bw/day
- Remarks:
- 24 h preparation interval
- Dose / conc.:
- 2 000 mg/kg bw/day
- Remarks:
- 24 h preparation interval
- Dose / conc.:
- 2 000 mg/kg bw/day
- Remarks:
- 48 h preparation interval:
- Positive control(s):
- 40 mg/kg b.w. cyclophosphamide administered orally was used as positive control which showed a substantial increase of induced micronucleus frequency.
Examinations
- Tissues and cell types examined:
- Polychromatic erythrocytes (PCE) in the bone marrow of the mouse.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- In conclusion, it can be stated that under the experimental conditions reported, the test item did not induce micronuclei as determined by the micronucleus test with bone marrow cells of the mouse.
Therefore, TSE-1 is considered to be non-mutagenic in this micronucleus assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
