Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-440-1 | CAS number: 2437-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
The percentage degradation of test substance Dodecanenitrile was determined to be 100% after a period of 3 days. Thus, based on percentage degradation, Dodecanenitrile is considered to be readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Dodecanenitrile (CAS No. 2437 -25 -4). If released in to the environment,17.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Dodecanenitrile in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in waterand the exposure risk to aquatic animals is moderate to low whereas the half-life period of Dodecanenitrile in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.06%), indicates that Dodecanenitrile is not persistent in sediment.
Biodegradation in soil
The half-life period of Dodecanenitrile (CAS No. 2437 -25 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment 78.9% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Dodecanenitrile in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Dodecanenitrile, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various experimental studies and predicted data for the target compound Dodecanenitrile (CAS No. 2437-25-4) and supporting studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from peer reviewed journal (Jackie Aislabie et. al; 1988), biodegradation experiment was conducted for 45 days for evaluating the percentage biodegradability of test substance Dodecanenitrile (CAS no. 2437-25-4) under aerobic conditions at a temperature of 28°C and pH of 7.5, respectively. A bacterial strain Pseudomonas fluorescens was used as a test inoculum isolated from the undecanenitrile broth platings and identified by using Rapid NFT Strips (API Systems S.A.) and also isolated directly from the original enrichment culture by plating onto 0.1 strength Trypticase soy broth (BBL Microbiology Systems) solidified with purified agar (Difco). It was identified as a strain of Pseudomonas aeruginosa by using the Rapid NFT Strips.Pseudomonas fluorescens strain was grown in nitrogen-free medium with 0.1% glucose and 1% shale oil (identical conditions as the parent enrichment culture with the shale oil as the sole nitrogen but not the sole carbon source) or Bushnell-Haas medium with 0.3% shale oil (shale oil as the sole carbon but not the sole nitrogen source). Several soil sources contaminated with petroleum, including soils from oily-sludge land farming and drill cores, were used as sources of inocula for enrichment cultures.Ten grams of each soil was added to 100 ml of a nitrogen-free medium containing (in grams per liter): MgSO4, 0.2; CaCl2, 0.02; KH2PO4, 1; K2HPO4, 1; FeCl3, 0.05. The pH was adjusted to 7.5, and the medium was then autoclaved. After sterilization the medium was amended with a sterile glucose solution to give a final concentration of 0.1% (wt/vol) and shale oil to give a concentration of 1% (wt/vol).Theshale oil was thus the sole source of nitrogen but not the sole source of carbon for these enrichments.The enrichments were incubated at 28°C on a rotary shaker at 200 rpm. The enrichment cultures have been maintained by monthly transfers into fresh medium. Initial test substance concentration used for the study was1000 mg/l.After 7 days of incubation with the aliphatic nitriles as substrates, hexamethylbenzene (HMB) was added as an internal standard, and the nitriles were recovered from the broth by extraction with methylene chloride.The ability of bacterium to utilize these individual nitriles as sole nitrogen and carbon sources was determined by gas-liquid chromatography with a flame ionization detector and the chromatographic conditions.The percentage degradation of test substance Dodecanenitrile was determined to be 100% after a period of 3 days. Thus, based on percentage degradation, Dodecanenitrile is considered to be readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance Dodecanenitrile (CAS no. 2437-25-4) (from secondary source U.S. Environmental Protection Agency, 2012 and HPVIS, 2017). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) under aerobic conditions. Activated sludge, domestic was used as a test inoculum for the study. The percentage degradation of test substance Dodecanenitrile was determined to be15% by ThOD parameter in 28 days. Thus, based on percentage degradation, Dodecanenitrile is considered to be not readily biodegradable in nature.
In a prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound Dodecanenitrile (CAS no. 2437 -25 -4) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical Dodecanenitrile is expected to be readily biodegradable.
For theread across substance Nonanenitrile (CAS no. 2243-27-8) from authoritative database (J-CHECK, 2017 and EnviChem, 2014), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance Nonanenitrile (CAS no. 2243-27-8). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance Nonanenitrile was determined to be 69, 83 and 100% by BOD, TOC removal and GC parameter in 28 days. Thus, based on percentage degradation, Nonanenitrile is considered to be readily biodegradable in nature.
In a supporting study from peer reviewed journal (Jackie Aislabie et. al; 1988) for read across substanceUndecanenitrile (CAS no. 2244-07-7), biodegradation experiment was conducted for 45 days for evaluating the percentage biodegradability of read across substance Undecanenitrile under aerobic conditions at a temperature of 28°C and pH of 7.5, respectively. A bacterial strain Pseudomonas fluorescens was used as a test inoculum isolated from the undecanenitrile broth platings and identified by using Rapid NFT Strips (API Systems S.A.) and also isolated directly from the original enrichment culture by plating onto 0.1 strength Trypticase soy broth (BBL Microbiology Systems) solidified with purified agar (Difco). It was identified as a strain of Pseudomonas aeruginosa by using the Rapid NFT Strips.Pseudomonas fluorescens strain was grown in nitrogen-free medium with 0.1% glucose and 1% shale oil (identical conditions as the parent enrichment culture with the shale oil as the sole nitrogen but not the sole carbon source) or Bushnell-Haas medium with 0.3% shale oil (shale oil as the sole carbon but not the sole nitrogen source). Several soil sources contaminated with petroleum, including soils from oily-sludge land farming and drill cores, were used as sources of inocula for enrichment cultures.Ten grams of each soil was added to 100 ml of a nitrogen-free medium containing (in grams per liter): MgSO4, 0.2; CaCl2, 0.02; KH2PO4, 1; K2HPO4, 1; FeCl3, 0.05. The pH was adjusted to 7.5, and the medium was then autoclaved. After sterilization the medium was amended with a sterile glucose solution to give a final concentration of 0.1% (wt/vol) and shale oil to give a concentration of 1% (wt/vol).The shale oil was thus the sole source of nitrogen but not the sole source of carbon for these enrichments.The enrichments were incubated at 28°C on a rotary shaker at 200 rpm. The enrichment cultures have been maintained by monthly transfers into fresh medium. Initial test substance concentration used for the study was 1000 mg/l.After 7 days of incubation with the aliphatic nitriles as substrates, hexamethylbenzene (HMB) was added as an internal standard, and the nitriles were recovered from the broth by extraction with methylene chloride.The ability of bacterium to utilize these individual nitriles as sole nitrogen and carbon sources was determined by gas-liquid chromatography with a flame ionization detector and the chromatographic conditions. The percentage degradation of read across substance Undecanenitrile was determined to be100% after a period of 3 days. Thus, based on percentage degradation, Undecanenitrile is considered to be readily biodegradable in nature.
On the basis of overall results for target chemical Dodecanenitrile (from peer reviewed journal, secondary source and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, EnviChem and peer reviewed journal), it can be concluded that the test substance Dodecanenitrile can be expected to be readily biodegradable in nature.
Biodegradation in water and sediment
Various predicted data for the target compound Dodecanenitrile (CAS No. 2437-25-4) were reviewed for the biodegradation in water and sediment end point which are summarized as below:
In aprediction done using the Mackay fugacity model level III of Estimation Programs Interface (EPI Suite, 2017)was run to predict the half-life in water and sediment for the test compound Dodecanenitrile (CAS No. 2437 -25 -4). If released in to the environment,17.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Dodecanenitrile in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Dodecanenitrile in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.06%), indicates that Dodecanenitrile is not persistent in sediment.
In a supporting study from secondary source (Robust Summary & Test Plans: Fatty Nitrogen Derived Nitriles Category, 2003 and High Production Volume (HPV) Challenge Program, 2017),half-life of the chemical Dodecanenitrile (CAS No: 2437-25-4) in water and sediment was estimated by using Mackay EQC Fugacity Level III.The following values has been used in the Mackay EQC Fugacity Level III for the estimating the half-life value. They are vapour pressure: 0.00628 mm Hg, log Kow: 4.9 and Henry’s law constant: 0.000848 atm-m3/mole, respectively. If released into the environment, 66.8% of the chemical will partition into water according to the Mackay EQC Fugacity Level III and the half-life period of Dodecanenitrile in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by Mackay EQC Fugacity Level III) indicates that the chemical Dodecanenitrile is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Dodecanenitrile in sediment is estimated to be 60 days (1440 hrs). Based on this half-life value of test chemical Dodecanenitrile, it is concluded that the chemical Dodecanenitrile is not persistent in the sediment environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of above results for target chemical Dodecanenitrile (from EPI suite, 2017 and secondary source), it can be concluded that the test substance Dodecanenitrile is not persistent in the water and sediment environment and therefore the exposure risk to aquatic and soil dwelling animals is moderate to low.
Biodegradation in soil
Various predicted data for the target compound Dodecanenitrile (CAS No. 2437-25-4) were reviewed for the biodegradation in soil end point which are summarized as below:
The half-life period of Dodecanenitrile (CAS No. 2437 -25 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment 78.9% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Dodecanenitrile in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Dodecanenitrile, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
In a supporting study from secondary source (Robust Summary & Test Plans: Fatty Nitrogen Derived Nitriles Category, 2003 and High Production Volume (HPV) Challenge Program, 2017), half-life of the chemical Dodecanenitrile (CAS No: 2437-25-4) in soil was estimated by using Mackay Equilibrium concentration (EQC) Fugacity Level III (v 1.01) model. The following values has been used in the Mackay EQC Fugacity Level III for the estimating the half-life value. They are vapour pressure: 0.00628 mm Hg, log Kow: 4.9 and Henry’s law constant: 0.000848 atm-m3/mole, respectively. If released into the environment, 0.038% of the chemical will partition into soil according to the Mackay EQC Fugacity Level III. The half-life period of Dodecanenitrile in soil is estimated to be 15 days (360 hrs). Based on this half-life value of test chemical Dodecanenitrile, it is concluded that the chemical Dodecanenitrile is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of above results for target chemical Dodecanenitrile (from EPI suite, 2017 and secondary source), it can be concluded that the test substance Dodecanenitrile is not persistent in the soil environment and therefore the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance Dodecanenitrile can be considered to be readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)